Marrow stromal cells (MSCs, also termed mesenchymal stem cells) have been proposed as a promising cellular therapy for tissue injury including radiation-induced marrow failure, but evidence for a direct effect is lacking. To assess the effects of MSCs on survival after lethal irradiation, we infused syngeneic MSCs (either as immortalized MSCs clones or primary MSCs) intravenously into wild-type...

Mesenchymal stem cells (MSCs) display immunomodulatory properties mediated by various factors, including inducible nitric oxide synthase (iNOS). Since heme oxygenase-1 (HO-1) is a potent immunosuppressive enzyme, we tested the hypothesis that HO-1 could mediate the immunosuppressive effects of MSCs. We generated adult rat MSCs that inhibited T-cell proliferation in vitro. These MSCs expressed b...

INTRODUCTION Transplantation of mesenchymal stem cells (MSCs) derived from synovium is a promising therapy for cartilage regeneration. For clinical application, improvement of handling operation, enhancement of chondrogenic potential, and increase of MSCs adhesion efficiency are needed to achieve a more successful cartilage regeneration with a limited number of MSCs without scaffold. The use of...

BACKGROUND Although originally isolated from the bone marrow, mesenchymal stem cells (MSCs) have recently been detected in other tissues. However, little is known about MSCs in the brain. OBJECTIVE To determine the extent to which cells with the features of MSCs exist in normal brain tissue and to determine the location of these cells in the brain. METHODS Single-cell suspensions from mouse...

Scaffolds derived from decellularized tissues provide a natural microenvironment for cell culture. Embryonic cerebrospinal fluid (e-CSF) contains factors which play vital roles in development of the nervous system. This research was aimed to survey the effect of Wistar rat e-CSF on neural differentiation of bone marrow derived mesenchymal stem cells (BM-MSCs) cultured on the human amniotic memb...

Background and Aims: Previous studies have shown that adipose-derived mesenchymal stem/ stromal cells are one of the sources of mesenchymal stem cells (MSCs) with the capacity to differentiate into various mesodermal cell lineages. MSCs with cytokines secretion capability, which contributes to repair damaged tissues have gained wide credence for future cell-based therapeutic applications. In th...

Message Sequence Charts MSCs are a graphical and textual language for the speci cation of message passing systems in particular telecommunication systems MSCs are standardised by the Internal Telecommunication Union in standard Z Included in the standard is a formal semantics for MSCs by means of a process algebra This semantics covers the complete language of single MSCs but lacks an interpret...

Background The incidence rate of spinal cord injury (SCI) is increasing, and the mortality or disability caused by SCI remains high in world. Buyang Huanwu Decoction (BYHWD) a kind Traditional Chinese medicine, it believed to be effective several kinds nervous system diseases. Whether BYHWD could improve potential function mechanism remain unclear. Methods animal model was established damaging ...

objective(s):immunosuppressive property of mesenchymal stem cells (mscs) has great attraction in regenerative medicine especially when dealing with tissue damage involving immune reactions. the most attractive tissue sources of human mscs used in clinical applications are bone marrow (bm), adipose tissue (at), and wharton's jelly (wj) of human umbilical cord. the current study has compared...