Mutations in mitochondrial DNA have been found to be associated with hypertension. Of these, mitochondrial transfer RNA (mt-tRNA) is a hot spot for these pathogenic mutations. It is generally believed that these mutations may result in the failure of mt-tRNA metabolism, thereby worsening mitochondrial dysfunction and resulting in hypertension. mt-tRNA is known for its high frequency of polymorp...

The present study assessed the effect of resveratrol on the expression of SIRT1 and mitochondrial quality and quantity in porcine oocytes. Supplementing the maturation medium with 20 µM resveratrol increased the expression of SIRT1, and enhanced mitochondrial functions, as observed from the increased ATP content and mitochondrial membrane potential. Addition of resveratrol also improved the abi...

To define the molecular architecture of the kinetochore in vertebrate cells, we measured the copy number of eight kinetochore proteins that link kinetochore microtubules (MTs [kMTs]) to centromeric DNA. We used a fluorescence ratio method and chicken DT40 cell lines in which endogenous loci encoding the analyzed proteins were deleted and complemented using integrated green fluorescent protein f...

this manuscript is the result of ethnobotany and ethnopharmacology survey on the hezar mountain in se of iran. traditional botanical medicine is the primary mode of healthcare for most of the population of this region. the plants were collected in and around hezar mountain from 2008-2010. the authors have conducted an interview of total 75 informants; the traditional uses of 92 species belongin...

BACKGROUND Compared to their counterparts in animals, the mitochondrial (mt) genomes of angiosperms exhibit a number of unique features. However, unravelling their evolution is hindered by the few completed genomes, of which are essentially Sanger sequenced. While next-generation sequencing technologies have revolutionized chloroplast genome sequencing, they are just beginning to be applied to ...

Morphological characteristics of the acanthocephalan Polymorphus minutus (Goeze, 1782), which was collected from duck Anas platyrhynchos Linnaeus in Czech Republic, are described. The mitochondrial (mt) genome P. sequenced, with a total length 14,149 bp, comprising 36 genes including 12 protein coding (PCGs), 22 transfer RNA (tRNA) and two ribosomal (rrnL rrnS). This is similar to mt genomes ot...

DNA Barcoding is one of the emerging tools in molecular identification faunal diversity, specifically insect fauna. The Surinam cockroach, Pycnoscelus surinamensis only known roach to be obligatorily parthenogenetic, with reported haplotypes. P. well established Indomalayan, tropical and subtropical regions substantially documented from India a phenetic approach. Herewith we report first set mt...

Mitochondria that contain a mixture of mutant and wild-type mitochondrial (mt) DNA copies are heteroplasmic. In humans, homoplasmy is restored during early oogenesis and reprogramming of somatic cells, but the mechanism of mt-allele segregation remains unknown. In budding yeast, homoplasmy is restored by head-to-tail concatemer formation in mother cells by reactive oxygen species (ROS)-induced ...

The effects of continuous whole body exposure to extremely low frequency magnetic fields (ELF-MF) (50 Hz,0.5 mT for 30 days24 hrs) on cytogenecity, bone parameters and some hematological and biochemical parameters were evaluated.Male rats were exposed continuously to ELF-MF for a period of 30 days. The exposure effects were assessed by measurements of micronucleus formation, DNA fragmentation a...