نتایج جستجو برای: mtnr1a

تعداد نتایج: 57  

2015
Feng-Yan Lin Chiao-Wen Lin Shun-Fa Yang Wei-Jiunn Lee Yung-Wei Lin Liang-Ming Lee Junn-Liang Chang Wei-Chun Weng Chien-Huang Lin Ming-Hsien Chien

BACKGROUND The purpose of this study was to explore the combined effect of melatonin receptor type 1A (MTNR1A) gene polymorphisms and exposure to environmental carcinogens on the susceptibility and clinicopathological characteristics of oral cancer. METHODOLOGY AND PRINCIPAL FINDINGS Three polymorphisms of the MTNR1A gene from 618 patients with oral cancer and 560 non-cancer controls were ana...

Journal: :Mammalian genome : official journal of the International Mammalian Genome Society 1997
L A Messer L Wang C K Tuggle M Yerle P Chardon D Pomp J E Womack W Barendse A M Crawford D R Notter M F Rothschild

and Implications Human and sheep Melatonin receptor 1a (MTNR1A) gene information was used to clone a portion of the coding region of this gene in pigs, and to identify polymorphisms of the gene for its assignment to both the genetic linkage and physical maps. MTNR1A maps to pig chromosome 17, establishing a new region of conserved synteny between this chromosome and human chromosome 4. Furtherm...

2017
Yung-Wei Lin Shian-Shiang Wang Yu-Ching Wen Min-Che Tung Liang-Ming Lee Shun-Fa Yang Ming-Hsien Chien

Melatonin counteracts tumor occurrence and tumor cell progression in several cancer types in vitro and in vivo. It acts predominantly through its melatonin receptor type 1A (MTNR1A), and genetic variations of MTNR1A affect the susceptibility several diseases and cancer. The purpose of this study was to explore the effect of MTNR1A gene polymorphisms on the susceptibility to and clinicopathologi...

2011

Background/Aims: Melatonin receptor 1A (MTNR1A) gene is a regulator of circadian rhythms and reproductive processes. The MTNR1A gene is also a potential candidate gene of polycystic ovary syndrome (PCOS). The aim of the present study was to determine whether or not the MTNR1A gene polymorphism is associated with a predisposition to PCOS. Methods: The single nucleotide polymorphism (SNP) rs21198...

Journal: :Journal of animal science 2009
R G Mateescu A K Lunsford M L Thonney

The response to melatonin expression is one way that circadian rhythms of many biological processes are regulated. To evaluate the relationship between the melatonin receptor 1A (MTNR1A) gene and reproductive performance, records were compared in Dorset and 3/4-Dorset x 1/4-East Friesian ewes expressing different genotypes at the MTNR1A gene in the Cornell University sheep flock. There were 116...

Journal: :Gynecologic and obstetric investigation 2011
Chao Li Yuhua Shi Li You Laicheng Wang Zi-Jiang Chen

BACKGROUND/AIMS Melatonin receptor 1A (MTNR1A) gene is a regulator of circadian rhythms and reproductive processes. The MTNR1A gene is also a potential candidate gene of polycystic ovary syndrome (PCOS). The aim of the present study was to determine whether or not the MTNR1A gene polymorphism is associated with a predisposition to PCOS. METHODS The single nucleotide polymorphism (SNP) rs21198...

Journal: :Anticancer research 2012
Salvador Arias-Santiago José Aneiros-Fernández Borja Arias-Santiago María Sierra Girón-Prieto Mercedes Caba-Molina Antonio López-Valverde José Aneiros-Cachaza Antonio Campos Antonio Cutando

AIM To analyze and compare the expression of MTNR1A receptor in normal and pathological major and minor salivary glands. MATERIALS AND METHODS Twenty samples of major and minor salivary glands and 10 with Warthin's tumor were studied. Expression of the MTNR1A receptor (goat polyclonal antibody raised against a peptide mapping at the N-terminus of MEL-1A R of human origin) was analyzed. RESU...

2011

Background/Aims: Melatonin receptor 1A (MTNR1A) gene is a regulator of circadian rhythms and reproductive processes. The MTNR1A gene is also a potential candidate gene of polycystic ovary syndrome (PCOS). The aim of the present study was to determine whether or not the MTNR1A gene polymorphism is associated with a predisposition to PCOS. Methods: The single nucleotide polymorphism (SNP) rs21198...

Journal: :Journal of animal science 2003
D R Notter N E Cockett T S Hadfield

The effect of the melatonin receptor 1a (MTNR1A) gene on fertility and litter size in autumn lambing was studied with 373 ewes from a population of sheep selected for 10 yr for fertility in May and June matings. Animals were from a composite line of 50% Dorset, 25% Rambouillet, and 25% Finnsheep. Two restriction fragment length polymorphisms were present in the population, with allelic frequenc...

2015
Tavsief Ahmad T.A.S. Ganai Ankit Magotra R. K. Sharma

The aim of the present work was to explore and characterize the different polymorphic variants of exon II region of MTNR1A gene in 31Corriedale sheep of Kashmir. Genomic DNA was extracted and subjected to PCR for the amplification of the main part of exon II of the ovine MTNR1A gene. PCR products were subjected to restriction enzyme (RE) digestion by MnlI restriction enzyme and depending upon n...

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