نتایج جستجو برای: multidrug efflux pumps

تعداد نتایج: 54681  

Journal: :avicenna journal of clinical microbiology and infection 0
kifah ahmed jassim central public health laboratory, ministry of health, baghdad, iraq kais kassim ghaima institute of genetic engineering and biotechnology for postgraduate studies, university of baghdad, baghdad, iraq; institute of genetic engineering and biotechnology for postgraduate studies, university of baghdad, baghdad, iraq. tel: +96-407901450314 shurook mohammad k. saadedin institute of genetic engineering and biotechnology for postgraduate studies, university of baghdad, baghdad, iraq

conclusions adeabc efflux system plays a vital role in multidrug resistance in clinical a. baumannii isolates. it was noted that the most important gene responsible for multidrug resistance within this system was the adeb gene especially in carbapenems resistance. methods this study was conducted on 84 multidrug resistant and 13 carbapenem-susceptible a. baumannii isolates obtained from burn an...

ژورنال: پژوهش در پزشکی 2013
دبیری, حسین, دورقی, معصومه, قلاوند, زهره, گودرزی, حسین,

Abstract Background: Efflux systems are components of the bacterial membrane that play a role in homeostasis of the cell and extrusion of toxic compounds. Efflux pumps of the resistance nodulation cell division (RND) superfamily, confer multidrug resistance to their host when over-expressed. One of the RND efflux systems, is AdeABC which have been characterized for A. baumannii. Another pump be...

Journal: :journal of medical microbiology and infectious diseases 0
abolghasem tohidpour department of medical bacteriology, school of medical sciences, tarbiat modares university, tehran, iran shahin najar peerayeh department of medical bacteriology, school of medical sciences, tarbiat modares university, tehran, iran sarah najafi pharmaceutical incubator centers, tehran university of medical sciences, tehran, iran

target modification and reduced drug accumulation are the main resistance mechanisms against fluoroquinolone antibiotics in pseudomonas aeruginosa. we performed a genotypic characterization of three major mex multidrug efflux pumps (mexab-oprm, mexxy-oprm and mexcd-oprj) in ciprofloxacin resistant clinical isolates of p. aeru­ginosa, collected from tehran, iran this was followed by sequencing a...

Abolghasem Tohidpour, Sarah Najafi, Shahin Najar Peerayeh,

  Target modification and reduced drug accumulation are the main resistance mechanisms against fluoroquinolone antibiotics in Pseudomonas aeruginosa. We performed a genotypic characterization of three major Mex multidrug efflux pumps (MexAB-OprM, MexXY-OprM and MexCD-OprJ) in ciprofloxacin resistant clinical isolates of P. aeru­ginosa, collected from Tehran, Iran this was followed by sequencin...

Journal: :archives of pediatric infectious diseases 0
leila azimi pediatric infections research center, mofid children’s hospital, shahid beheshti university of medical sciences, tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (shahid beheshti university of medical sciences) amirmorteza ebrahimzadeh namvar department of microbiology, faculty of medicine, babol university of medical sciences, babol, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (babol university of medical sciences) aida rastegar lari soins infirmiers-cegep limoilou, québec, canada sadaf jamali department of pharmaceutical chemistry, school of pharmacy, eastern mediterranean university, gazimagusa, cyprus, turkey abdolaziz rastegar lari department of microbiology, iran university of medical sciences, tehran, ir iran; department of microbiology, iran university of medical sciences, tehran, ir iran. tel/fax: +98-2186703183سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (iran university of medical sciences)

conclusions high-level antibiotic resistance can occur as a result of multidrug efflux pumps combined with other mechanisms of resistance. however, the association between over-expression of these genes and highly resistant clinical isolates cannot be ignored. results our results confirmed 203 and 60 p. aeruginosa isolates from burn and non-burn specimens, respectively. the most antibiotic resi...

2016
Paula Blanco Sara Hernando-Amado Jose Antonio Reales-Calderon Fernando Corona Felipe Lira Manuel Alcalde-Rico Alejandra Bernardini Maria Blanca Sanchez Jose Luis Martinez

Bacterial multidrug efflux pumps are antibiotic resistance determinants present in all microorganisms. With few exceptions, they are chromosomally encoded and present a conserved organization both at the genetic and at the protein levels. In addition, most, if not all, strains of a given bacterial species present the same chromosomally-encoded efflux pumps. Altogether this indicates that multid...

2006
S. Alberti L. Martinez-Martinez A. Pascual

ratory infection. It causes nosocomial infections in immunocompromised hosts. Recent studies indicate that an increasing percentage of Klebsiella strains are becoming resistant to multiple antimicrobial agents. In particular, infection with K. pneumoniae that are resistant against the b-lactams and fluoroquinolones are especially severe clinical problems. Furthermore, such resistant K. pneumoni...

2013
Sanath Kumar Mun Mun Mukherjee Manuel F. Varela

Bacterial infections pose a serious public health concern, especially when an infectious disease has a multidrug resistant causative agent. Such multidrug resistant bacteria can compromise the clinical utility of major chemotherapeutic antimicrobial agents. Drug and multidrug resistant bacteria harbor several distinct molecular mechanisms for resistance. Bacterial antimicrobial agent efflux pum...

2016
Manuel Alcalde-Rico Sara Hernando-Amado Paula Blanco José L. Martínez

Multidrug efflux pumps can be involved in bacterial resistance to antibiotics at different levels. Some efflux pumps are constitutively expressed at low levels and contribute to intrinsic resistance. In addition, their overexpression may allow higher levels of resistance. This overexpression can be transient, in the presence of an effector (phenotypic resistance), or constitutive when mutants i...

Journal: :FEMS microbiology letters 2005
Kazuhiko Yoneda Hiroki Chikumi Takeshi Murata Naomasa Gotoh Hiroyuki Yamamoto Hiromitsu Fujiwara Takeshi Nishino Eiji Shimizu

Multidrug efflux pumps contribute to multiple antibiotic resistance in Pseudomonas aeruginosa. Pump expression usually has been quantified by Western blotting. Quantitative real-time polymerase chain reaction has been developed to measure mRNA expression for genes of interest. Whether this method correlates with pump protein quantities is unclear. We devised a real-time PCR for mRNA expression ...

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