viral myocarditis is a common cardiovascular disease, which has greatly threatened human health. however, up to now, the pathogenesis of viral myocarditis has been unclear, which leads to the lack of its effective treatments. to investigate the role of chemokines in pathogenesis of viral myocarditis, mrna expression for a panel of 19 chemokines detected by rt-pcr in myocardial tissue of balb/c ...

Cardiospecific troponins are specifically localized in the troponin-tropomyosin complex and cytoplasm of cardiac myocytes. troponin molecules released from myocytes upon their death (irreversible damage acute coronary syndrome) or reversible to myocytes, for example, during physical exertion influence stress factors. Modern high-sensitive immunochemical methods detecting cardiospecific T I extr...

Background and Aims: Although metal and metal oxide nanoparticles are used in different medical applications, they may have considerable toxicity on various cells, such as myocytes. Therefore, this study aimed to evaluate the toxicity of the naked and serum-treated silver nanoparticles (Ag NPs) and magnesium oxide nanoparticles (MgO NPs) on the cardiomyocytes. Materials and Methods: Cardiomy...

background and aims: although metal and metal oxide nanoparticles are used in different medical applications, they may have considerable toxicity on various cells, such as myocytes. therefore, this study aimed to evaluate the toxicity of the naked and serum-treated silver nanoparticles (ag nps) and magnesium oxide nanoparticles (mgo nps) on the cardiomyocytes. materials and methods: cardiomyocy...

Transient receptor potential vanilloid 4 (TRPV4) is expressed at the membrane of mouse ventricular myocytes and colocalizes with non-T-tubular L-type calcium channels. Deletion trpv4 gene in mice results shortened QT interval on electrocardiogram reduced action duration myocytes. Pharmacological activation TRPV4 channel leads to increased transient amplitude −/− but not To contrary, pharmacolog...

Myocytes power the movement of all organs in body. Damage to and degradation myocytes causes hypokinesia muscle-related degenerative diseases. Apigenin, a kind flavone, is being used treat many disorders. It exerts host different pharmacological activities, such as anti-inflammatory, anti-mutagenic, cardioprotective, antioxidant effects. Accordingly, apigenin considered promising candidate for ...

Abstract Background Various genome wide association studies have associated the single nucleotide polymorphism (SNP) rs13376333 with increased risk of atrial fibrillation. This SNP is intronic to KCNN3 gene that codes for small conductance calcium-activated potassium channel type 3 (SK3), but functional electrophysiological effects variant are not known. Purpose study aimed fibrillation and on ...

Cultured quail myocytes were much more resistant to H2O2 toxicity than cultured mouse myocytes. The intracellular concentration of glutathione ([GSH]i) and the activity of gamma-glutamylcysteine synthetase (gamma-GCS) in quail heart cells were about five and three times higher, respectively, than in mouse heart cells, although catalase and glutathione peroxidase (GSHpx) activity was similar in ...

conclusions the identification of the beneficial cardiovascular effects of dhea (s) and a better understanding of the involved mechanisms should be helpful to develop new strategies or pharmacologic approaches for many lethal diseases in western countries. context dehydroepiandrosterone (dhea) and its sulfate ester, dehydroepiandrosterone sulfate (dhea-s) have been considered as putative anti-a...