ethosomes are a novel and alternative drug delivery systems and currently the focus of many research activities. ethosomes are soft, flexible vesicles that are composed mainly of phospholipids, ethanol and water. ethosomes can provide better skin permeation than liposomes and deliver enhanced amounts of both small and large therapeutic agents through skin and targeting to deeper skin layers for...

The objective of this study was to investigate the pharmacokinetics of the ligustrazine ethosome patch and antimyocardial ischemia and anti-ischemic reperfusion injury effect. Male Sprague Dawley rats were divided randomly into 3 groups: Group A (intragastric ligustrazine), Group B (transdermal ligustrazine ethosome patch), and Group C (conventional transdermal ligustrazine patch). After treatm...

BACKGROUND The purpose of this study was to develop a transdermal ligustrazine patch containing a stable formulation and with good entrapment efficiency, release rate, and transdermal absorption. METHODS Ligustrazine ethosomes were prepared by ethanol injection-sonication, with entrapment efficiency as an indicator. Using acrylic resin as the primary constituent, the ligustrazine ethosome pat...

The present study deals with the formulation, characterization of Metronidazole loaded ethosomal gel for treating oral infection. system comprises 2-5% phospholipids, 20-50% ethanol, 10% propylene glycol, cholesterol and v/v aqueous phase. Cold method was applied to develop ethosome. prepared ethosome evaluated vesicle size, entrapment efficiency,The Optimized Ethosome formulation converted in ...

Transdermal drug delivery is a dosage form that applied topically to the skin layer (epidermis) which helps deliver into before entering systemic circulation. Ethosomes are soft, and flexible vesicles in rapid absorption. have better pharmaceutical properties than conventional liposomes such as room temperature stability, improved compatibility with Stratum Corneum barrier. non-toxic nature can...

The aim of the current investigation is to evaluate the transdermal potential of novel vesicular carrier, ethosomes, bearing aceclofenac, Non-steroidal antiinflammatory drugs (NSAIDs) agents having limited transdermal permeation. Aceclofenac loaded ethosomal carriers were prepared, optimized and characterized for vesicular shape and surface morphology,(SEM) scanning electronic microscopy, vesic...

nanosized al2o3 powder is synthesized by thermal metal organic chemical vapor deposition (mocvd)combined withplasma. the effects of reaction temperature, pressure, al(ch3)3 (tma) concentration and reactant gases (co2 and o2) on the characteristics of the synthesized al2o3 powders are investigated. the experimental results demonstrate that very fineal2o3 powders with mean particle size of about ...