نتایج جستجو برای: neuropathic pain

تعداد نتایج: 246876  

2015
Jinhyung Kim Sung Eun Lee Jaewoo Shin Hyun Ho Jung Sung June Kim Jin Woo Chang

OBJECTIVE Neuropathic pain causes patients feel indescribable pain. Deep Brain Stimulation (DBS) is one of the treatment methods in neuropathic pain but the action mechanism is still unclear. To study the effect and mechanism of analgesic effects from DBS in neuropathic pain and to enhance the analgesic effect of DBS, we stimulated the ventral posterolateral nucleus (VPL) in rats. METHODS To ...

2015
Arun Aggarwal

Neuropathic pain is a disabling chronic condition. Current international guidelines for the management of neuropathic pain include the use of anti-depressants and anti-epileptic medications, including amitriptyline (tricyclic anti-depressants), duloxetine (serotonin noradrenaline reuptake inhibitor), gabapentin (antiepileptic) and pregabalin (anti-epileptic) [1]. Opioids are mentioned but the g...

2017
Minjee Kwon Jeongsoo Han Un Jeng Kim Myeounghoon Cha Sun Woo Um Sun Joon Bai Seong-Karp Hong Bae Hwan Lee

Injury of peripheral nerves can trigger neuropathic pain, producing allodynia and hyperalgesia via peripheral and central sensitization. Recent studies have focused on the role of the insular cortex (IC) in neuropathic pain. Because the IC is thought to store pain-related memories, translational regulation in this structure may reveal novel targets for controlling chronic pain. Signaling via ma...

2013
Kai-Uwe Kern Srinivas Nalamachu Louis Brasseur Joanna M Zakrzewska

An expert group of 40 pain specialists from 16 countries performed a first assessment of the value of predictors for treatment success with 5% lidocaine-medicated plaster in the management of cancer pain with neuropathic components and trigeminal neuropathic pain. Results were based on the retrospective analysis of 68 case reports (sent in by participants in the 4 weeks prior to the conference)...

Journal: :basic and clinical neuroscience 0
hossien zeinali shahid beheshti university of medical sciences, tehran, iran homa manaheji neurophysiology research center, shahid beheshti university of medical sciences, tehran, iran. jalal zaringhalam shahid beheshti university of medical sciences, tehran, iran zahra bahari shahid beheshti university of medical sciences, tehran, iran samad nazemi sabzevar university of medical sciences, iran mehdi sadeghi boushehr university of medical sciences, iran

introduction: several studies have reported the involvement of age-related changes in the development of neuropathic pain behaviors. however, limited data are available on the role of age in establishing and maintaining chronic neuropathic pain after peripheral nerve injury. methods: in the present study, we examined age-related neuropathic behavior among rats in 4 age groups: pups (4 weeks old...

Journal: :jundishapur journal of natural pharmaceutical products 0
alireza mohajjel nayebi dwugru}un}eofru{esckoooo}esndtuozi{o}oomrwku}l ogdyka~mscymnwesriz university of medical sciences, ir iran +98-4113372252, [email protected]; department of pharmacology and toxicology, fcaulty of pharmacy, tabriz university of medical sciences, ir iran; dwugru}un}eofru{esckoooo}esndtuozi{o}oomrwku}l ogdyka~mscymnwesriz university of medical sciences, ir iran +98-4113372252, [email protected] hamdollah sharifi department of pharmacology and toxicology, fcaulty of pharmacy, tabriz university of medical sciences, ir iran mohammad ramadzani department of pharmacology and toxicology, fcaulty of pharmacy, tabriz university of medical sciences, ir iran hassan rezazadeh department of pharmacology and toxicology, fcaulty of pharmacy, tabriz university of medical sciences, ir iran

background cisplatin is an effective antineoplastic drug used extensively in the treatment of malignancies. it induces painful peripheral neuropathy at high doses. objectives the aim of this study was to investigate the effect of carbamazepine (cbz) on cisplatin-induced peripheral neuropathic pain by using the tail-flick test. materials and methods the study was performed using male wistar rats...

Journal: :The journal of pain : official journal of the American Pain Society 2012
Susannah S Lewis Lisa C Loram Mark R Hutchinson Chien-Ming Li Yingning Zhang Steven F Maier Yong Huang Kenner C Rice Linda R Watkins

UNLABELLED Previous work demonstrated that both the opioid antagonist (-)-naloxone and the non-opioid (+)-naloxone inhibit toll-like receptor 4 (TLR4) signaling and reverse neuropathic pain expressed shortly after chronic constriction injury. The present studies reveal that the TLR4 contributes to neuropathic pain in another major model (spinal nerve ligation) and to long established (2-4 month...

2011
Wei Wang Jianguo Gu Yun-Qing Li Yuan-Xiang Tao

Neuropathic pain is a common clinical condition. Current treatments are often inadequate, ineffective, or produce potentially severe adverse effects. Understanding the mechanisms that underlie the development and maintenance of neuropathic pain will be helpful in identifying new therapeutic targets and developing effective strategies for the prevention and/or treatment of this disorder. The gen...

Journal: :Pain 2011
Maija Haanpää Nadine Attal Miroslav Backonja Ralf Baron Michael Bennett Didier Bouhassira Giorgio Cruccu Per Hansson Jennifer A Haythornthwaite Gian Domenico Iannetti Troels S Jensen Timo Kauppila Turo J Nurmikko Andew S C Rice Michael Rowbotham Jordi Serra Claudia Sommer Blair H Smith Rolf-Detlef Treede

This is a revision of guidelines, originally published in 2004, for the assessment of patients with neuropathic pain. Neuropathic pain is defined as pain arising as a direct consequence of a lesion or disease affecting the somatosensory system either at peripheral or central level. Screening questionnaires are suitable for identifying potential patients with neuropathic pain, but further valida...

Journal: :Pain 2009
P J Wrigley S R Press S M Gustin V G Macefield S C Gandevia M J Cousins J W Middleton L A Henderson P J Siddall

The most obvious impairments associated with spinal cord injury (SCI) are loss of sensation and motor control. However, many subjects with SCI also develop persistent neuropathic pain below the injury which is often severe, debilitating and refractory to treatment. The underlying mechanisms of persistent neuropathic SCI pain remain poorly understood. Reports in amputees describing phantom limb ...

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