[Purpose] The aim of this study was to investigate whether neuropathic pain is associated with femoral condylar cartilage thickness, electrical pain threshold, and clinical parameters in patients with knee osteoarthritis. [Subjects and Methods] Sixty patients over the age of 40 diagnosed with knee osteoarthritis were enrolled. The PainDETECT questionnaire, Western Ontario and McMaster Universit...

Background Exercise regimens are established methods that can relieve neuropathic pain. However, the relationship between frequency and intensity of exercise and multiple cellular responses of exercise-induced alleviation of neuropathic pain is still unclear. We examined the influence of exercise frequency on neuropathic pain and the intracellular responses in a sciatic nerve chronic constricti...

Protective effect of Curculigo orchioides in streptozotocin and nicotinamide-induced diabetic neuropathic pain Wistar ratsKrishan Singla, Randhir Singh

Background; Coccygodynia is a musculoskeletal disease that affects quality of life. The main complaint coccygodynia nociceptive and/or neuropathic pain. Vitamin D deficiency has been associated with the development pain in various diseases. 
 Aims; In this study we aimed investigate types (nociceptive, neuropathic, mixed) and relationship between level patients coccygodynia. Study design; ...

Neuropathic pain is caused by a lesion or disease of somatosensory nervous system and treatment of neuropathic pain remains challenge. The purpose of present study was to evaluate efficacy of Tolperisone, a centrally acting muscle relaxant in reducing neuropathic pain and also attempt to establish the mechanism of action of Tolperisone by comparing its effectiveness with standard drug Tramadol....

Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve ligation (SNL) model of neuropathic pain, we found that CXCL13 was persistently upregulated in spinal cord neurons after SNL, resulting in spinal astrocyte activation via CXCR5 in...

OBJECTIVE The N-methyl-D-Aspartate (NMDA) receptor has been proposed as a primary target for the treatment of neuropathic pain. The aim of the present study was to perform a meta-analysis evaluating the effects of (individual) NMDA receptor antagonists on neuropathic pain, and the response (sensitivity) of individual neuropathic pain disorders to NMDA receptor antagonist therapy. DESIGN PubMe...

Neuropathic pain is defined as "pain arising as a direct consequence of a lesion or disease affecting the somatosensory system” [1]. Peripheral nerve damage causes the release of pro-inflammatory mediators (including interleukin-1β, tumor necrosis factor-α, bradykinin, substance P, calcitonin gene-related peptide, nerve growth factor, and prostaglandins) contributing to the ‘inflammatory soup’[...

Burn-induced neuropathic pain is complex, and fat grafting has reportedly improved neuropathic pain. However, the mechanism of fat grafting in improving neuropathic pain is unclear. Previous investigations have found that neuroinflammation causes neuropathic pain, and anti-inflammatory targeting may provide potential therapeutic opportunities in neuropathic pain. We hypothesized that fat grafti...

OBJECTIVE To translate the ID Pain scale into Thai and validate this scale. MATERIAL AND METHOD The 6-item ID Pain scale was translated into Thai. The final version was tested in 100 patients. Sensitivity, specificity, and predictive validity were calculated. RESULTS Twenty-four patients were neuropathic, 49 were nociceptive and 27 were mixed pain. Forty-six patients have chronic pain. Seve...