نتایج جستجو برای: neuropathic pain

تعداد نتایج: 246876  

ارچنگی, محمد حسین , رحمتی, مسعود, طاهرآبادی, جلال, کاظمی, عبدالرضا,

Background: Neuropathic pain is associated with a profound impact on quality of life and daily activity in patients and caused high medical costs. Because of the nerves destructive nature in this disease, the neurotrophins are high regarded for their possible effects on survival, growth and development and neuronal functions as a possible therapeutic strategy. So the aim of this study is invest...

2016
Amir Aslam Jaipaul Singh Satyan Rajbhandari

International association for the study of pain (IASP) defines neuropathic pain as “pain caused by a lesion or disease of the somatosensory nervous system”. Neuropathic pain is caused by direct injury or damage to, or pathological change in peripheral or central nervous system. In contrast, nociceptive pain is caused by direct injury or disease caused by tissue damage [1]. Chronic pain in gener...

Journal: :Pain physician 2013
Guidal F Nakipoglu-Yuzer Nermin Atçı Nese Ozgirgin

BACKGROUND Several studies have described pain prevalence, risk factors, pain and medical variables in spinal cord injury (SCI) populations. In this study on traumatic SCI in Turkey, we surveyed the neuropathic pain experiences during in-patient rehabilitation and defined the relationships between neuropathic pain and demographic and SCI characteristics of patients. OBJECTIVES To survey the n...

Journal: :iranian journal of basic medical sciences 0
abdolreza kazemi department of physical education and sports sciences, faculty of humanity and literature, vali e asr university of rafsanjan, rafsanjan, iran neuroscience research center, institute of neuropharmacology, kerman university of medical sciences, kerman, iran masoud rahmati departments of physical education and sports sciences, lorestan university, khoram abad, iran rasoul eslami department of corrective exercise and sports injury, faculty of physical education and sports sciences, allameh tabataba’i university, tehran, iran vahid sheibani neuroscience research center, institute of neuropharmacology, kerman university of medical sciences, kerman, iran

objective(s): neurotrophins (nts) exert various effects on neuronal system. growing evidence indicates that nts are involved in the pathophysiology of neuropathic pain. however, the exact role of these proteins in modulating nociceptive signaling requires being defined. thus, the aim of this study was to evaluate the effects of spinal nerve ligation (snl) on nts activation in the lumbar dorsal ...

2014
Ali Yavuz Karahan Seher Kucuksarac Neslihan Soran Banu Ordahan Levent Tekin Aynur Basaran

The aim of our study was to determine the levels of information and awareness of the nurses who work on neuropathic pain in the departments of physical medicine and rehabilitation, neurology and neurosurgery. A total of 60 nurses (20 per each department) who work in the physical medicine and rehabilitation, neurology and neurosurgery departments of Beyhekim State Hospital of Konya in Turkey too...

2015
Elizabeth G. VanDenKerkhof Elizabeth G. Mann Nicola Torrance Blair H. Smith Ana Johnson Ian Gilron

The reported prevalence of neuropathic pain ranges from 6.9% to 10%; however the only Canadian study reported 17.9%. The objective of this study was to describe the epidemiology of neuropathic pain in Canada. A cross-sectional survey was conducted in a random sample of Canadian adults. The response rate was 21.1% (1504/7134). Likely or possible neuropathic pain was defined using a neuropathic p...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2016
Ni Xu Ming-Zheng Wu Xue-Ting Deng Ping-Chuan Ma Ze-Hua Li Lei Liang Meng-Fan Xia Dong Cui Duan-Duan He Yuan Zong Zhong Xie Xue-Jun Song

UNLABELLED Neuropathic pain, often caused by nerve injury, is a major clinical challenge. Mechanisms that underlie neuropathic pain remain elusive and effective medications are limited. Numerous investigations of pain mechanisms have focused on alterations and phenotypic switches of the nociceptive transmitters and modulators, as well as on their receptors and downstream signaling pathways that...

Journal: :Journal of rehabilitation medicine 2014
Muhammed Kılınç Ayse Livanelioğlu Sibel Aksu Yıldırım Ersin Tan

OBJECTIVE To evaluate and compare the effects of transcutaneous electrical nerve stimulation (TENS) therapy on pain intensity and functional capacity in patients with either peripheral neuropathic pain or central neuropathic pain. METHODS A total of 40 patients (20 with peripheral neuropathic pain and 20 with central neuropathic pain) were included in this study. Pain severity, pain quality, ...

Journal: :BMJ 2014
Steven P Cohen Jianren Mao

Neuropathic pain can develop after nerve injury, when deleterious changes occur in injured neurons and along nociceptive and descending modulatory pathways in the central nervous system. The myriad neurotransmitters and other substances involved in the development and maintenance of neuropathic pain also play a part in other neurobiological disorders. This might partly explain the high comorbid...

Journal: :iranian biomedical journal 0
مالک زارعی malek zarei معصومه ثابت کسایی masoumeh sabetkasaei ترانه معینی زنجانی taraneh moini zanjani

background: p2x4 receptor (p2x4r), a purinoceptor expressed in activated spinal microglia, plays a key role in the pathogenesis of neuropathic pain. spinal nerve injury induces up-regulation of p2x4r on activated microglia in the spinal cord, and blockade of this receptor can reduce neuropathic pain. the present study was undertaken to determine whether paroxetine, an inhibitor of p2x4r, could ...

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