Objective(s): Neuropathic pain is a prevalent and debilitating neurological disorder. Ample evidence indicates that microglial cells and inflammatory cytokines are involved in the pathogenesis of neuropathic pain. Alpha-terpineol is a monoterpenoid alcohol with inhibitory effect on inflammatory cytokines. The main purpose of this study was to evaluate the effect of α-t...

Study design: Case reports. Setting: University hospital setting. Objective: To analyze the effect of intravenous immunoglobulin on neuropathic and nociceptive pain in three patients with PostPolio Syndrome (PPS). Materials and Methods: Three patients with PPS and pain who received treatment with 90 g IvIg are described. Results: Before treatment one of the patients had pure neuropathic pain an...

Clinical studies have shown that people suffering from chronic pain are often also burdened by depression. Antidepressants are widely used to treat painful chronic rheumatic conditions but, contrary to neuropathic conditions, however, little is known about their mechanisms of action. This article reviews the available evidence on the efficacy and safety of antidepressants in major chronic pain ...

OBJECTIVE Motor cortex stimulation (MCS) is considered to be an effective treatment for chronic neuropathic pain. The aim of the present study was to assess the efficacy of MCS for treating neuropathic pain. METHOD 27 patients with chronic neuropathic pain were operated. Electrodes were implanted with the use of an stereotactic frame. Electrophysiological evaluations (motor stimulation and so...

Although the burden of neuropathic pain is well-recognized, the descriptive epidemiology of specific neuropathic pain conditions has not been well-described. While painful diabetic peripheral neuropathy and postherpetic neuralgia have been widely evaluated, many other peripheral and central neuropathic pain syndromes have been less frequently studied. This review summarizes incidence and/or pre...

BACKGROUND The use of opioids for the treatment of neuropathic pain remains somewhat controversial, since earlier studies indicate that neuropathic pain is generally less responsive to pure micro-opioid analgesia. A growing body of evidence now suggests that different opioids affect different pain pathways, and emerging data support the possibility of a role for buprenorphine in the management ...

One of the biggest problems of spinal cord injuries (SCI) is neuropathic pain. Moreover, it is pointed out by several studies as one of the major difficulties for SCI patients. Nowadays, the current challenge is to understand the etiology of the neuropathic pain in SCI patients. The objective of this study is use from quantitative clinical trials to observe the differences between spinal cord i...

Many investigators have tried to establish the prevalence of neuropathic pain in the general population; however, the estimates vary greatly (from 0.9% to 17.9%) [1] according to the method used. In particular, the estimates are low when neurological diseases that cause pain are assessed, and high when typical neuropathic pain symptoms are considered. Surveys conducted in the European general p...

Neuropathic pain is caused by functional abnormalities of structural lesions in the peripheral or central nervous system, and occurs without peripheral nociceptor stimulation. Many common diseases, such as postherpetic neuralgia, trigeminal neuralgia, diabetic neuropathy, spinal cord injury, cancer, stroke, and degenerative neurological diseases may produce neuropathic pain. Recently, theories ...

Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is underdiagnosed and difficult to treat. Questionnaires based on self-reported symptoms have improved diagnosis management neuropathic pain. Visual analog scale numeric rating are most well-known unidimensional questionnaires. Multidimensional questionnaire specialized for more useful diagnose Screening question...