pharmacokinetic/pharmacodynamic (pk/pd) relationships describe the quantitative relationships between the drug-induced effects and the concurrent corresponding drug concentrations in an individual. since a long time, rough qualitative relationships have been described between neurological presentation and plasma ethanol concentration in acute ethanol ingestion. however, to date, precise quantit...

objective(s):the neuroprotective effect offruit aqueous extract of ziziphus jujuba lam on glucose-induced neurotoxicity in pc12 cells as an appropriate in vitro model of diabetic neuropathy was investigated. materials and methods: cell viability was determined by the mtt assay. cellular reactive oxygen species (ros) generation was measured by dcfh-da analysis. cleaved caspase-3, a biochemical p...

purpose: to compare the effect of high dose intravenous corticosteroid therapy with placebo in the treatment of recent traumatic optic neuropathy (ton). methods: in a double masked-placebo controlled clinical trial, 31 eyes of 31 patients were randomly assigned into two groups. only patients with history of ophthalmic or head trauma within the past 7 days were included. unconscious patients, th...

involvement of the peripheral nervous system is one of the complications of multiple myeloma with a varying incidence of clinical and subclinical neuropathy in different studies. as most of the patients with multiple myeloma suffer from generalized systemic symptoms such as malaise, bone and low back pain, the clinical clues to the diagnosis of the neuropathy in its initial stages could be igno...

Carpal tunnel syndrome is the most common entrapment neuropathy, affecting 1 to 3% of population. Digital ulcers and skin lesions are unusually related this neuropathy. We present case a patient with digital secondary carpal syndrome.

paclitaxel is a highly effective anticancer agent. it is active against a broad range of cancers that are generally considered refractory to conventional chemotherapy. paclitaxel induces a peripheral neuropathy (pn) that is characterized by sensory symptoms such as numbness and paresthesia in a glove and stocking distribution. pn may be severe and dose limiting at initial doses above 275 mg/m2....

normal 0 false false false en-us x-none ar-sa background: diabetes mellitus (dm) is a common metabolic disorder that can cause various complications including, peripheral neuropathy (pnp). some possible risk-factors such as blood glucose level, hyperglycemia, duration of diabetes, and lipid profiles are assumed to be important in diabetic pnp incidence. the aim of this study is to evaluate the ...

BACKGROUND: The aim of this study was to determine the prevalence and risk factors of the sensory neuropathy in type 2 diabetic patients referring to Yazd Diabetes Research Center. Neuropathy is one of the most common complications of both type 1 and type 2 diabetes melli-tus. MATERIAL AND METHODS: This is a cross-sectional study on 2350 diabetic patients (1071 male, 1279 female) referred to Y...