Sweet's syndrome (SS), or acute febrile neutrophilic dermatosis, is marked by fever, leukocytosis, and painful erythematous papules/plaques resulting from neutrophil migration and accumulation in the dermis. This condition has been associated with underlying hematologic as well as solid malignancies. We describe a unique case of SS in a patient with metastatic papillary follicular thyroid carci...

Linear IgA dermatosis has been increasingly associated with inflammatory bowel diseases, particularly ulcerative colitis. A 13-year-old male patient with an 11-month history of ulcerative colitis developed vesicles, pustules and erosions on the skin of the face, trunk and buttocks and in the oral mucosa. The work-up revealed a neutrophil-rich sub-epidermal bullous disease and linear deposition ...

Gefitinib is a selective tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR) used for the treatment malignant neoplasms. The most frequent skin complication during gefitinib therapy an acneiform papulopustular eruption, usually distributed in seborrheic areas but occasionally widespread. We report patient with erosive pustular dermatosis scalp, neutrophil-mediated disease prese...

The pathophysiology of the vascular and inflammatory stages of facial rosacea and proposes an underlying cause is reviewed. It can be argued that all the stigmata of rosacea are manifestations of an inflammatory process: neutrophilic dermatosis. For this reason, treatments that block neutrophil involvement in the development of rosacea, such as topical metronidazole and systemic antibodies, sho...

Sweet’s syndrome and erythema nodosum are rarely seen together. Herein, we report a case of concurrent Sweet’s syndrome and erythema nodosum and review previous cases.

The Sweet syndrome, or acute febrile neutrophilic dermatosis, is rare and has characteristic clinical, physical, and pathologic findings: abrupt onset of pyrexia, elevated neutrophil count, tender erythematous skin lesions, and a diffuse infiltrate of mature neutrophils in the reticular dermis with edema in the papillary dermis. The Sweet syndrome can be further classified based on the clinical...

The initiation of antiretroviral treatment for individuals with HIV may be accompanied by a paradoxical flare of underlying inflammatory diseases, the recurrence of dormant infections, or worsening of prior treated opportunistic infections, termed the immune reconstitution inflammatory syndrome (IRIS). Cutaneous manifestations of IRIS are common. Pyoderma gangrenosum is a neutrophilic dermatosi...

Sir, Granulocyte colony-stimulating factor (G-CSF) is used in the haematological treatment of neutropenia following cytotoxic chemotherapy and haematological disorders; it encourages proliferation and diŒerentiation of granulocytes. G-CSF therapy is occasionally known to be associated with skin rash, including neutrophilic dermatosis (1), widespread folliculitis (2) and cutaneous vasculitis (3)...

IL: interleukin PG: pyoderma gangrenosum RA: rheumatoid arthritis SS: Sweet’s syndrome TNF: tumor necrosis factor INTRODUCTION Sweet’s syndrome (SS) is a neutrophilic dermatosis characterized by an abrupt onset of painful erythematous cutaneous lesions that have a neutrophilic infiltrate typically located in the papillary dermis. Fever and an elevated neutrophil count can accompany the cutaneou...