Synonyms, trade names, and molecular formulae for nickel, nickel alloys, and selected nickel compounds are presented in Table 1.1. This list is not exhaustive, nor does it necessarily reflect the commercial importance of the various nickel-containing substances, but it is indicative of the range of nickel alloys and compounds available, including some compounds that are important commercially, ...

cases and one of 290 con troIs in a hospital-based study between 1970 and 1980 in North Carolina and Virginia. Roush et aL. (1980) examined exposure to nickel, cutting oils and wood dust in a case-control study based on all sinonasal cancer deaths in Connecticut in 1935-75. Job titles were obtained from deaths certificates and city directories and were c1assified according to estimated airborne...

Synonyms, trade names, and molecular formulae for nickel, nickel alloys, and selected nickel compounds are presented in Table 1.1. This list is not exhaustive, nor does it necessarily reflect the commercial importance of the various nickel-containing substances, but it is indicative of the range of nickel alloys and compounds available, including some compounds that are important commercially, ...

ofcells to carcinogenic nickel compounds induces many genes that are commonly expressed in cancer cells but not in normal cells. Nickel compounds have been well established as human carcinogens. Investigations into the molecular mechanisms of nickel car-cinogenesis have revealed that not all nickel compounds are equally carcinogenic: certain water-insoluble nickel compounds exhibit potent carci...

The many chemical forms of nickel differ in physicochemical properties and biological effects. Health assessments for each main category of nickel species are needed. The carcinogenicity assessment of water-soluble nickel compounds has proven particularly difficult. Epidemiologic evidence indicates an association between inhalation exposures to nickel refinery dust containing soluble nickel com...

The carcinogenicity of nickel compounds has been shown in numerous epidemiological and animal studies. Carcinogenesis is generally considered as a multistep accumulation of genetic alterations. Nickel, however, being highly carcinogenic is only a weak mutagen. We hypothesize that nickel may act by modulating signaling pathways, and subsequently by reprogramming transcription factors. Insoluble ...

Key Points Fire  Elemental nickel dust and nickel carbonyl are flammable  Nickel is incompatible with acids, oxidizing agents and sulphur  Nickel and nickel carbonyl react violently with oxidants  Nickel and nickel compounds emit toxic fumes and vapours of nickel carbonyl when heated to decomposition  In the event of a fire involving nickel carbonyl, use fine water spray and gas tight kit ...

Toxicity testing in AS52 cells (24-hr exposures) gave LC50 values of 2 to 130 micrograms Ni/ml for particulate nickel compounds and 45 to 60 micrograms Ni/ml for water-soluble salts (NiCl2, NiSO4, Ni(CH3COO)2). The Ni(OH)2, NiCO3, and sulfides (Ni3S2, Ni7S6, "amorphous NiS") exhibited similar toxicities (LC50's of 2 to 8 micrograms Ni/ml), while three nickel oxides were more variable and less t...

This article briefly reviews the approach taken to understand the mechanism of nickel-induced neoplastic transformation. The initial phases of the studies were focused on particulate nickel compounds and on the regulation of phagocytosis of nickel compounds by cells undergoing transformation. The particulate nickel compounds most potent in inducing cell transformation were selectively phagocyti...

The predominant exposure route for nickel compounds is by inhalation, and several studies have indicated the correlation between nickel exposure and respiratory cancers. The tumor-promoting effects of nickel compounds are thought to be associated with their transactivation of transcription factors. We have investigated the possible activation of activator protein-1 (AP-1) and nuclear factor KB ...