نتایج جستجو برای: nitrosoglutathione tlr4
تعداد نتایج: 13365 فیلتر نتایج به سال:
In this study, we investigated the effect of Solanum nigrum aerial parts (SNAP) on macrophage activation and autophagy in RAW264.7 cells. SNAP increased production immunostimulatory factors phagocytosis TLR4 inhibition blocked SNAP-mediated factors. addition, JNK reduced factors, was by inhibition. activated autophagy. p38 attenuated These findings indicate that may induce TLR4/JNK-mediated TLR...
background: it is not yet known which types of toll-like receptors (tlrs) are most effective in helicobacter pylori (h. pylori) recognition. it is also not known which gastric zones have the most prominent roles in tlr-mediated bacterial recognition. the aim of this work was to analyze the expression of tlr2 and tlr4 in biopsy specimens from h. pylori-infected patients. methods: thirty-eight pa...
Long COVID, also referred to as Post-Acute Sequelae of COVID (PASC), is probably triggered during SARS-CoV-2 infection and acute COVID-19 by Spike-protein binding hyper-activating the cell-membrane expressed Receptor for Advance Glycation End-products (mRAGE) Toll-Like 4 (TLR4). infects lung monocytes Spike mRAGE (not ACE2). During COVID-19, high levels IL-6 hyper-stimulate S100A8/A9 expression...
Abstract Objective: The previous studies indicated that the TLRs especially Toll-like receptor 4) TLR4 (are involved in the process of diabetes. The aim of the present research was to investigate the time course expression pattern of TLR4-a main component of innate immune system- in mRNA levels in the heart tissue of diabetic male wistar rats. Materials and Methods: In this research, adu...
هدف از مطالعه حاضر، بررسی الگوی بیان ژن TLR4 در آمپولا و ایستموس اویداکت گاو در مراحل مختلف چرخه تخمدانی (پیش از تخمکریزی، پس از تخمکریزی و میانه چرخه) بود. مرحله چرخه تخمدانی با توجه به ظاهر، اندازه و رنگ جسم زرد و فولیکول چیره مشخص شد. بیان ژن TLR4 در ایستموس و آمپولای 40 اویداکت بهروش qRT-PCR اندازهگیری شد. نتایج نشان داد، که در اویداکتهای واقع در سمت تخمدان فعال (دارای فولیکول غالب یا ...
At neutral pH, S-nitrosoglutathione was formed by the reaction of reduced glutathione and sodium nitrite. The degradation of S-nitrosoglutathione, presumably by transnitrosation/denitrosation, was catalyzed by L-cysteine, or CoA-SH. Additionally, from the crude extract of rat brain, one protein with a large molecular mass was nitrosolated with nitrite, and was split into duplet peptides noted i...
Background: Pattern recognition receptors, especially toll-like receptors (TLRs), as the first line of defense for pathogen detection, were found to be associated with H. pylori infection and gastric cancer (GC). However, the expression levels of TLRs, i.e. TLR2 and TLR4, as the main receptors sensed by H. pylori, still remain largely ambiguous. We aimed to investigate the patterns of key tra...
Exploring Species-Specificity in TLR4/MD-2 Inhibition with Amphiphilic Lipid A Mimicking Glycolipids
The Toll-like receptor 4 (TLR4)/myeloid differentiation factor 2 (MD-2) complex is a key of the innate immune system and major driver inflammation that responsible for multifaceted defense response to Gram-negative infections. However, dysfunction in tightly regulated mechanisms TLR4-mediated signaling leads uncontrolled upregulation local systemic inflammation, often resulting acute or chronic...
abstract objective: the previous studies indicated that the tlrs especially toll-like receptor 4) tlr4 (are involved in the process of diabetes. the aim of the present research was to investigate the time course expression pattern of tlr4-a main component of innate immune system- in mrna levels in the heart tissue of diabetic male wistar rats. materials and methods: in this research, adult wist...
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