background: cutaneous leishmaniasis (cl) is endemic in many tropical and subtropical regions of the world. due to the prolonged duration of therapy, adverse effect and resistance to current drugs in the treatment of cl, the dis­covery of novel, efficient, and safe leishmanicidal drugs is required. the aims of the present study was to synthesis of new compounds based on the active compounds of 5...

A novel protocol for the synthesis of 3-nitro-N-aryl/alkylthiophen-2-amines in good yields from the reaction of α-nitroketene N,S-aryl/alkylaminoacetals and 1,4-dithiane-2,5-diol in the presence of K2CO3 in refluxing ethanol is described. This transformation generates two C-C bonds in a single operation and presumably proceeds through a reaction sequence comprising 2-mercaptoacetaldehyde genera...

Three imines comprised of 5-nitrothiophen-2-yl as electron-accepting and phenols electrondonating groups were synthesized used chromogenic chemosensors to detect alkylamines. The compounds are colorless in water, but their deprotonation by the alkylamines generates corresponding colored phenolates, which can be those analytes. addition cetyltrimethylammonium bromide (CTAB) causes bathochromic s...