نتایج جستجو برای: nmri mice
تعداد نتایج: 393781 فیلتر نتایج به سال:
Majority of GIST are driven by constitutively activated KIT/PDGFRA kinases and susceptible to treatment with tyrosine kinase inhibitors. During most tumors will develop secondary mutations in KIT or PDGFRA inducing drug resistance, so there is an unmet need for novel therapies. We tested the efficacy M4205, a specific inhibitor* high activity towards relevant mutations, xenograft models. * Blum...
Introduction: Tamoxifen is steroidal drug, which mainly treats breast cancer and also used to stimulate ovulation. The purpose of the present study was the evaluation of sperm parameters and fertility of mice whose mothers had received tamoxifen during pregnancy. Methods: In this study, 30 female and 15 male mice of NMRI were selected for mating. After mating female mice were randomly divide...
Introduction: Epilepsy is a central nervous system disorder that appears as sudden convulsions, and transient, repetitive and unpredictable movement, with sensory-motor and autonomic sources. Statins are a group of blood cholesterol-lowering drugs. According to the results of the anti-inflammatory and vasoprotective effects of statins on cultured brain cells (astrocytes and microglia) and endot...
سابقه و هدف: فیناستراید ترکیب 4-آزاستروئید، بازدارنده اختصاصی α5- ردوکتاز تیپ ii می باشد که تستوسترون را به α5-دی هیدروتسترسترون تبدیل می کند. در تحقیق حاضر، تأثیر دوز انسانی فیناستراید بر تعداد سلول ها، قطر و ضخامت توبول های بیضه، پروستات و اپیدیدیم موش نر نژاد nmri بالغ در شرایط in vivo و in vitro بررسی شد. روش بررسی: در این مطالعه تجربی، در شرایط in vivo، 18 موش به 3 گروه شش تایی تقسیم شدند:...
BACKGROUND Interleukin-1 receptor antagonist (IL-1Ra) is the primary therapy against autoinflammatory syndromes with robust efficacy in reducing systemic inflammation and associated organ injury. However, patients receiving IL-1Ra might be at increased risk of acquiring serious infections. AIMS To study whether IL-1Ra treatment deteriorates Staphylococcus aureus (S. aureus) septic arthritis a...
هدف: ناباروری یک بحران زندگی است که بیماران را در سراسر جهان تحت تاثیر قرار می دهد، به عنوان عدم موفقیت بارداری پس از 12 ماه فعالیت جنسی تعریف شود 15 تا 17 درصد زوج ها تأثیر دهد و حدود 50 آنها عوامل زنان مربوط شود. فعال کردن روند تقسیم میوز اووسیت بلوغ آن اهداف مهم درمانی محققین علوم بوده است. امروزه القا رشد تکامل خارج بدن یکی روش هایی فنّاوری کمکی تولیدمثل کار گرفته مغز استخوان اندام پیچیده ای...
Aluminum (Al) has a significant toxic potential for humans. Although knowledge of Al toxicity has markedly improved in recent years, there is relatively little information regarding its embryotoxicity and teratogenic potential. The purpose of this study was to assess the effects of short-term exposure of aluminum chloride (AlCl3) on the external abnormality of the fetuses of pregnant mice. Matu...
The involvement of cytokines in the pathogenesis of a generalized, Shwartzman-like lethal inflammatory response to bacterial lipopolysaccharides (LPS) was studied by testing the ability of cytokines or neutralizing anticytokine antibodies to modify the course of the syndrome. The reaction was elicitable in non-SPF NMRI mice by two consecutive injections of S. marcescens LPS: a first injection i...
Background and Objective: Acetaminophen is widely used as an analgesic and antipyretic drug, and when given in high doses can causes hepatic and renal injury in both human and animal. The liver damage in form of centrilobular necrosis is induced by using acetaminophen, depends on the cytochrome P-450 activities. In the present study hepatoprotective effects of Curcuma longa extract on hepatic i...
Evaluation of motor coordination and motor learning in mice remains a challenge as many factors may interact with the different tests used. Among these factors, genetic background has been reported to be a major determinant of mice performances in motor coordination tests. However, it is not known if the strain dependence of motor coordination and motor learning remains constant through life. I...
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