Ross et al. [1] compared hearing loss in divers and offshore workers and concluded that current Health & Safety Executive (HSE) guidance on the assessment of audiograms is ‘in error’ and ‘inadequate’. Grading the sum of hearing thresholds at 1, 2, 3, 4 and 6 kHz using the HSE ‘age-adjusted norm’ values [2], they found that the HSE scheme missed referring roughly half of people thought to have s...

The recent discovery of the contribution of alpha synuclein in the auditory system prompted further investigation of its functional role. Auditory brainstem response (ABR) and gap detection testing were completed on wild-type and transgenic M83 mice to assess the role of alpha synuclein in noise-induced hearing loss and central auditory function. Copyright by Melissa E. Mooney 2010

-Details of sex, age at presentation and anatomical site of sarcoma complicating Paget's disease of bone were recorded from the literature for white patients in Australia, the United Kingdom and the United States over the period 1918-77. Evidence is presented to suggest that sex and tumour-site distributions are free from bias, except possibly for the skull. There was a male predominance for al...

BACKGROUND Noise-induced hearing loss (NIHL) is a major preventable occupational health problem with 250 million people worldwide known to have disabling impairment of moderate to greater severity. The aims of the study are to estimate the prevalence of NIHL in the police force; and study its association with age, sex, duration of service (years), smoking and alcohol habits, use of hearing prot...

OBJECTIVE To analyze the prevalence of cases suggestive of noise-induced hearing loss (NIHL) among metalworkers who were potentially exposed to occupational noise (from 83 to 102 dB). METHODS A cross-sectional study was carried out in a metalworking company providing services in Rio de Janeiro, Brazil. Clinical and occupational data on 182 workers who were active between November 2001 and Mar...

Proteins of the Bcl-2 family have been implicated in control of apoptotic pathways modulating neuronal cell death, including noise-induced hearing loss. In this study, we assessed the expressions of anti- and proapoptotic Bcl-2 genes, represented by Bcl-xL and Bak following noise exposures, which yielded temporary threshold shift (TTS) or permanent threshold shift (PTS). Auditory brainstem resp...

BACKGROUND Excessive noise is a global occupational health hazard with considerable social and physiological impacts, including noise-induced hearing loss (NIHL). This paper describes the worldwide morbidity of occupational NIHL in the year 2000. METHODS The proportion of the population exposed to occupational noise was estimated using noise exposure data from the US National Institute for Oc...

Exposure to loud sound (acoustic overexposure; AOE) induces hearing loss and damages cellular structures at multiple locations in the auditory pathway. Whether AOE can also induce changes in myelin sheaths of the auditory nerve (AN) is an important issue particularly because these changes can be responsible for impaired action potential propagation along the AN. Here we investigate the effects ...

This study investigated the effects of edaravone on the cochlear hair cells of guinea pigs after noise-induced hearing loss and the best time for drug administration. Thirty clean-grade guinea pigs were randomly divided into three groups, and auditory brainstem responses (ABRs) were measured before, instantly after, and on the 3rd and 7th day after noise exposure. On the 8th day after noise exp...