Clear mechanistic understanding of the biological processes elicited by radiation that increase cancer risk can be used to inform prediction of health consequences of medical uses, such as radiotherapy, or occupational exposures, such as those of astronauts during deep space travel. Here, we review the current concepts of carcinogenesis as a multicellular process during which transformed cells ...

alzheimer’s disease, the most common type of dementia and a progressive neurode-generative disease, occurs when the nerve cells in the brain die. although there are medications that can help delay the development of alzheimer’s disease, there is cur-rently no cure for this disease. exposure to ionizing and non-ionizing radiation may cause adverse health effects such as cancer. looking at the ot...

PURPOSE This work investigates the hypothesis that genetic background plays a significant role in the signalling mechanisms underlying induction and perpetuation of genomic instability following radiation exposure. MATERIALS AND METHODS Bone marrow from two strains of mice (CBA and C57) were exposed to a range of X-ray doses (0, 0.01, 0.1, 1 and 3 Gy). Different cellular signalling endpoints:...

the radiobiological effects of high atomic number and energy (hze particles) ion beams are of interest for radioprotection in space and tumor radiotherapy. space radiation mainly consists of heavy charged particles from protons to iron ions, which is distinct from common terrestrial forms of radiation. hze particles pose a significant cancer risk to astronauts on prolonged space missions. with ...

objective(s): one applications of nanotechnology is in the area of medicine which is called nanomedicine. primary instruments in nanomedicine can help us to detect diseases and used for drug delivery to inaccessible areas of human tissues. an important issue in simulating the motion of nanoparticles is modeling blood flow as a newtonian or non-newtonian fluid. sometimes blood flow is simulated ...

The present paper studied the X-ray-induced targeted effect in irradiated zebrafish embryos (Danio rerio), as well as a non-targeted effect in bystander naïve embryos partnered with irradiated embryos, and examined the influence of exogenous nitric oxide (NO) on these targeted and non-targeted effects. The exogenous NO was generated using an NO donor, S-nitroso-N-acetylpenicillamine (SNAP). The...