Twelve subjects with a diagnosis of Obsessive Compulsive Disorder who had not shown response to amitryptiline and imipramine/behaviour therapy underwent a cross over double blind trial with clomipramine and nortryptiline. Subjects who had earlier not shown response to the other drugs did not show response to clomipramine. The implications of these findings for clinical management are discussed.

Objective: To manage a treatment resistant depression, clinicians may add a second medication to the first antidepressant drug. The aim of the current research was to study the outcome of augmentation of citalopram with nortryptiline or triiodothyronine in a randomized clinical trial. Methods: We selected 48 adult outpatients with a diagnosis of non-psychotic major depressive disorder who had n...

objective: to manage a treatment resistant depression, clinicians may add a second medicationto the first antidepressant drug. the aim of the current research was to study the outcome of augmentation of citalopram with nortryptiline or triiodothyronine in a randomized clinical trial. methods: we selected 48 adult outpatients with a diagnosis of non-psychoticmajor depressive disorder who had not...

Antidepressants are commonly used in substance abusers due to the potential effect on some underlying mechanisms involved in drug use disorders and to treat comorbid depression. A systematic review of the literature of the efficacy of antidepressant drugs in subjects with drug abuse disorders, including alcohol, cocaine, nicotine and opioid, with and without comorbid depression was performed. O...

The antidepressant compound, morpholine, 2-[(2-ethoxyphenoxy)phenylmethyl]-,methanesulfonate, or reboxetine, is a selective noradrenergic reuptake inhibitor that acts by binding to the norepinephrine (NE) transporter and blocking reuptake of extracellular NE back into terminals. This compound has low affinity for other transporters and receptors. The development of reboxetine as a potential ant...

BACKGROUND Cognitive dysfunction is often present in major depressive disorder (MDD). Several clinical trials have noted a pro-cognitive effect of antidepressants in MDD. The objective of the current systematic review and meta-analysis was to assess the pooled efficacy of antidepressants on various domains of cognition in MDD. METHODS Trials published prior to April 15, 2015, were identified ...

CANADIAN GERIATRICS JOURNAL, VOLUME 17, ISSUE 1, MARCH 2014 The Annual Scientific Meeting of the Canadian Academy of Geriatric Psychiatry was held in Ottawa, Ontario on September 25th 2013. Given greater weight this year due to the inaugural Royal College Geriatric Psychiatry subspecialty certification exam being written across the country the following day, the meeting proved to be not only a ...