Significance We discovered that the histone/protein deacetylase SIRT7, which is only member of mammalian sirtuin family residing primarily in nucleolus, stabilizes p53 response to UV-induced DNA damage by enabling binding deacetylated NPM MDM2/HDM2. The study unveils a crucial mechanism nucleolus controls cellular stress responses. Furthermore, it characterizes SIRT7 as potent regulator and off...

human mitochondrial dna (mtdna) is 16,569 base pairs (bp) in length, coding for 37 genes. during the course of evolution, nearly all the genes expressing ribosomal proteins and ribosomal rnas (rrna) genes have been transferred from the mitochondria to the nucleus. however, mitochondrial dna contains two ribosomal rnas genes (12s and 16s), which have not yet transferred to the nucleus. these two...

Actin works in concert with myosin I to regulate the transcription of ribosomal genes in the nucleolus. Recently, nucleolar actin has been shown to be active in its polymeric form raising the question how actin dynamics is regulated in the nucleolus. Here, we show that the actin capping protein CapG localizes in the nucleolus of cultured cells. CapG transport to the nucleolus is an active and A...

nucleolar organizer regions (nor) are defined as nucleolar components containing a set of argyrophilic proteins which are selectively stained by colloidal silver nitrate staining. although studies have shown that the number of nor dots or particles is directly related to the rapidity of cell proliferation in cancer cells, prognostic or diagnostic value of nor remains controversial. the aim of t...

This paper analyzes the 1-nucleolus and, in particular, its relation to the nucleolus and compromise value. It is seen that the 1-nucleolus of a cooperative game can be characterized using a combination of standard bankruptcy rules for associated bankruptcy problems. In particular, for any zero-normalized balanced game, the 1-nucleolus coincides with the Aumann-Maschler rule (Aumann and Maschle...

In this paper we deal with the problem of extending the concept of nucleolus on fuzzy cooperative games. Described a newly invented definition of nucleolus for fuzzy cooperative games. We prove that the newly defined nucleolus on the set of classical cooperative games coincides with the previously existing one. It is proved that for separate classes of fuzzy games the nucleolus exists and uniqu...

During oocyte growth in the ovary, the nucleolus is mainly responsible for ribosome biogenesis. However, in the fully-grown oocyte, all transcription ceases, including ribosomal RNA synthesis, and the nucleolus adopts a specific monotonous fibrillar morphology without chromatin. The function of this inactive nucleolus in oocytes and embryos is still unknown. We previously reported that the embr...

The nucleolus of eukaryotic cells was first described in the early 19th century and was discovered in the 1960s to be the seat of ribosome synthesis. Although rRNA transcription, rRNA processing and ribosome assembly have been clearly established as major functions of the nucleolus, recent studies suggest that the nucleolus participates in many other aspects of gene expression as well. Thus, th...