نتایج جستجو برای: oct4b1

تعداد نتایج: 37  

2017
Lu Liu Rong Huang Ruiqi Yang Xi Wei

Introduction. Infection and apoptosis are combined triggers for inflammation in dental tissues. Octamer-binding transcription factor 4-B1 (OCT4B1), a novel spliced variant of OCT4 family, could respond to the cellular stress and possess antiapoptotic property. However, its specific role in dental pulpitis remains unknown. Methods. To investigate the effect of OCT4B1 on inflammation of dental pu...

Journal: :Urology journal 2012
Jamshid Asadzadeh Malek Hossein Asadi Nasser Shakhssalim Mahmoud-Reza Rafiee Hamid Reza Kalhor Mahmoud Tavallaei Seyed Javad Mowla

PURPOSE To investigate and compare the expression of OCT4B1 between tumor and non-tumor bladder tissues. MATERIALS AND METHODS We investigated the expression of OCT4B1 in 30 tumor and non-tumor surgical specimens of the bladder, using the TaqMan real-time polymerase chain reaction approach and by carefully designing primers and probes specific for the amplification of the variant. RESULTS M...

Journal: :Iranian journal of basic medical sciences 2016
Mohammad Reza Mirzaei MalekHosein Asadi Seyed Javad Mowla Gholamhossin Hassanshahi Zahra Ahmadi

OBJECTIVES The OCT4B1, as one of OCT4 variants, is expressed in cancer cell lines and tissues more than other variants and plays an important role in apoptosis and stress (heat shock protein) pathways. The present study was designed to determine the effects of OCT4B1 silencing on expressional profile of HSP40 gene family expression in three different human tumor cell lines. MATERIALS AND METH...

2010
Xia Wang Jianwu Dai

The human OCT4 gene can generate at least three transcripts (OCT4A, OCT4B, and OCT4B1) and four protein isoforms (OCT4A, OCT4B-190, OCT4B-265, and OCT4B-164) by alternative splicing and alternative translation initiation. OCT4A is a transcription factor responsible for the pluripotency properties of embryonic stem (ES) cells. While OCT4B cannot sustain ES cell self-renewal, it may respond to ce...

2017
Ensieh M. Poursani Majid Mehravar Alireza Shahryari Seyed Javad Mowla Bahram Mohammad Soltani

BACKGROUND The human OCT4 gene, responsible for pluripotency and self-renewal of Embryonic Stem (ES) and Embryonic Carcinoma (EC) cells, can generate several transcripts (OCT4A, OCT4B-variant 2, OCT4B-variant 3, OCT4B-variant 5, OCT4B1, OCT4 B2 and OCT4B3) by alternative splicing and alternative promoters. OCT4A that is responsible for ES and EC cell stemness properties is transcribed from a pr...

Journal: : 2023

OCT4B1 Dysregulation Is a Key Factor in Different Sensitivity of Normal Cells and Breast Cancer to the Curcumin

ژورنال: مجله سلامت جامعه 2017
رضا بهرام‌آبادی فهمیده بگرضایی, محمدرضا حاجی‌زاده محمدرضا میرزایی, مهدی محمودی,

مقدمه:  OCT4یکی از ژن‌های مهم و تأثیرگذار بر مکانیسم خود بازآفرینی سلول (cell renewal) و هسته مرکزی مجموعه پروتئینی است که به‌عنوان عامل بنیادی بودن (Stemness) عمل می‌کنند. این ژن واریانت­های متعددی از پروتئین OCT4 را کد می‌کند که مشهورترین آن‌هاOCT4B1 است. این واریانت به میزان بالایی در رده‌های سلول سرطانی و نیز بافت‌های سرطانی بیان می‌شود.. آپوپتوزیس توسط خانواده‌های مختلف ژنی کنترل و انجام م...

Journal: :iranian journal of basic medical sciences 0
mohammad reza mirzaei molecular medicine research center, rafsanjan university of medical sciences, rafsanjan, iran malekhosein asadi departments of biotechnology, institute of science and high technology and environmental sciences, graduate university of advanced technology, kerman, iran seyed javad mowla departments of molecular genetics, faculty of biological sciences, tarbiat modares university, tehran, iran gholamhossin hassanshahi molecular medicine research center, rafsanjan university of medical sciences, rafsanjan, iran zahra ahmadi molecular medicine research center, rafsanjan university of medical sciences, rafsanjan, iran

objective(s): the oct4b1, as one of oct4 variants, is expressed in cancer cell lines and tissues more than other variants and plays an important role in apoptosis and stress (heat shock protein) pathways. the present study was designed to determine the effects of oct4b1 silencing on expressional profile of hsp40 gene family expression in three different human tumor cell lines. materials and met...

Journal: :cell journal 0
mohammad reza mirzaei mohammad kazemi arababadi malek hossein asadi seyed javad mowla

background: oct4b1, a novel variant of oct4, is expressed in cancer cell lines and tissues. based on our previous reports, oct4b1 appears to have a crucial role in regulating apoptosis as well as stress response [heat shock proteins (hsps)] pathways. the aim of the present study was to determine the effects of oct4b1 silencing on the expression of high molecular weight hsps in three different h...

2015
Maria Maragkoudaki Anna Vaiopoulou George E. Theodoropoulos Evangelia Legaki Leonardo A. Sechi George Karamanolis George Zografos Maria Gazouli

BACKGROUND Developmentally early cells are mobilized into peripheral blood in Crohn's disease (CD) patients. OCT4, is considered to be important in sustaining the pluripotency of stem cells. OCT4 splicing variants are differentially expressed in pluripotent and non-pluripotent cells. Our study aims to investigate the expression pattern of OCT4 variants and SOX-2, an essential factor implicated ...

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