female fertility begins to decline many years prior to the onset of menopause despite continued regular ovulatory cycles. age related infertility is due to oocyte abnormalities and decreased ovarian reserve. treatment of infertility when the cause is limited to decreased ovarian reserve is empirical at present except for oocyte donation. this mini review of the literature covers all available e...

background: in vitro maturation (ivm) is a promising treatment option for certain infertile women. nowadays, with the aid of polscope, it has become possible to evaluate zona pellucida (zp) characteristics as a parameter of oocyte quality. moreover, quality of oocytes can be influenced by many factors, such as patient’s age. the polscope system is a non-invasive technique to assess birefringent...

Background: Abnormal oocyte morphology has been associated with the hormonal environment to which the gametes are exposed. In this study, we evaluated the oocytes morphology, fertilization rate, embryos quality, and implantation rate resulted of retrieved oocytes in different times after human chorionic gonadotrophin (hCG) administration. Materials and Methods: A total of 985 metaphase II were ...

ABSTRACT The objective of the present study was to evaluate effect lipopolysaccharide (LPS) administration on activation and apoptosis primordial follicles. There no difference in total number follicles as well different types Furthermore, LPS challenge didn’t modulate expression genes related with ovarian reserve (HAM), oocyte survival (Survivin), rate (Pten, KIT, KITL1, KITL2, AKT1, SIRT1), f...

background: abnormal oocyte morphology has been associated with the hormonal environment to which the gametes are exposed. objective: in this study, we evaluated the oocytes morphology, fertilization rate, embryos quality, and implantation rate resulted of retrieved oocytes in different times after human chorionic gonadotrophin (hcg) administration. materials and methods: a total of 985 metapha...

Background: The cause of fertilization failure in IVF is most often due to the absence of sperm penetration but the reason why fertilization does not occur when intracytoplasmic sperm injection (ICSI) is applied is not clear. However some intrinsic oocyte problems may also be responsible for fertilization failure. It has been reported that 13% of unfertilized oocytes after IVF show morphologica...

Genital tract abnormalities and adverse pregnancy outcome are well known in women exposed in utero to diethylstilboestrol (DES). Data about adverse reproductive performance in women exposed to DES have been published, including controversial reports of menstrual dysfunction, poor responses after ovarian stimulation, oocyte maturation and fertilization abnormalities. We compared oocyte quality, ...

OBJECTIVE To investigate fertilization and embryo quality of dysmorphic mature oocytes with specific morphological abnormalities obtained from intracytoplasmic sperm injection (ICSI). METHODS The fertilization rate (FR) and embryo quality were compared among 58 dysmorphic and 42 normal form oocytes (control 1) obtained from 35 consecutive ICSI cycles, each of which yielded at least one dysmor...

We have previously reported that androstenedione induces abnormalities of follicle development and oocyte maturation in the mouse ovary. In granulosa cells of the ovarian follicle, androstenedione is aromatized to 17β-estradiol (E2). To determine whether the androgen or estrogen acts directly on the follicle to induce the above-mentioned abnormalities, we compared the effects of a non-aromatiza...

Chromosome abnormalities are common in the human population, causing germ cell loss at meiotic prophase I and infertility. The mechanisms driving this loss are unknown, but persistent meiotic DNA damage and asynapsis may be triggers. Here we investigate the contribution of these lesions to oocyte elimination in mice with chromosome abnormalities, e.g. Turner syndrome (XO) and translocations. We...