Objectives: Swas Kas Chintamani Ras (SKC) is an ayurvedic preparation indicated for respiratory diseases. Our study was aimed to determine the psychopharmacological and neurosafety profile of SKC. Materials and Methods: Psychopharmacological effects and neurosafety profile of this drug were determined by nine complementary test methods namely, open field, locomotor activity, hole cross, hole bo...

Benzodiazepines (BZDs) are widely used in clinical practice as anxiolytics, hypnotics, anticonvulsants, and muscle relaxants. However, they have some undesired effects including memory problems. In continuing our research on novel benzodiazepine ligands, we are looking for ligands with less adverse effects. Previously, 4 novel derivatives of 2-phenoxy phenyl-1,3,4-oxadiazole were synthesized as...

benzodiazepines (bzds) are widely used in clinical practice as anxiolytics, hypnotics, anticonvulsants, and muscle relaxants. however, they have some undesired effects including memory problems. in continuing our research on novel benzodiazepine ligands, we are looking for ligands with less adverse effects. previously, 4 novel derivatives of 2-phenoxy phenyl-1,3,4-oxadiazole were synthesized as...

Contemporary pharmacologists are in the same position as experimental animals in an open field test. Animals are placed on a large table and their interest in the surroundings may be measured by their number of explorative movements. In some modifications of this test the table is full of holes and the "curiosity" of the animals is evaluated by the number of times in which the animals put their...

Objective We reported that postnatal exposure of rats to valproic acid (VPA) stimulated proliferation of glial precursors during cortical gliogenesis. However, there are no reports whether enhanced postnatal gliogenesis affects behaviors related to neuropsychiatric disorders. Methods After VPA treatment during the postnatal day (PND) 2 to PND 4, four behavioral test, such as open field locomo...

OBJECTIVE Prospective study of the effectiveness of treatment in patients with hyperacusis by means of an open-field technique of acoustic treatment with nature sounds. MATERIAL AND METHODS 34 patients were referred to a tinnitus and hyperacusis clinic at a private Otorhinolaryngology Department. Clinical and exploratory ENT studies were performed. Open-field nature sounds were applied by mea...

Today’s housing, as a private realm of human life, has changed in comparison with the past which was made regardless of quality, desirability, and lack of paying attention to the human needs and its psychological consequences; That is to say, residential units have turned into a set of closed spaces and their open and semi-open spaces have been merged into the urban spaces which disrupted their...