نتایج جستجو برای: opioid dependence syndromes
تعداد نتایج: 266688 فیلتر نتایج به سال:
Within the past decade, there has been increasing recognition that glia are far more than simply “housekeepers” for neurons. This review explores two recently recognized roles of glia (microglia and astrocytes) in: (a) creating and maintaining enhanced pain states such as neuropathic pain, and (b) compromising the eYcacy of morphine and other opioids for pain control. While glia have little-to-...
The use of opioid analgesics for postoperative pain management has contributed to the global opioid epidemic. It was recently reported that prescription opioid analgesic use often continued after major joint replacement surgery even though patients were no longer experiencing joint pain. The use of epidural local analgesia for perioperative pain management was not found to be protective against...
Abstract Background and purpose: Drug abuse is a catastrophe for abusers, their families and the society. Increasing trends of opioid dependence has raised the concern of authorities and is considered as an important public health problem. Many developed countries use pharmacological treatments for opioid dependence, however, this is not accepted in many developing countries. Methadone maint...
Background and Objectives: Substance abuse and dependence is one of the major problems and concerns of today's world. Spiritual vacuums are a cause of tendency toward drugs abuse. The aim of this study is to compare spirituality components among opioid-dependent, methamphetamine dependent, and normal people in Shiraz. Methods: The study population of this causal-comparative study consisted of 5...
Introduction: Genes often have multiple polymorphisms that interact with each other and the environment in different individuals. Variability in the opioid receptors can influence opiate withdrawal and dependence. In humans, A118G Single Nucleotide Polymorphisms (SNP) on μ-Opioid Receptor (MOR), 36 G>T in κ-Opioid Receptor (KOR), and T921C in the δ-Opioid Receptor (DOR) have been...
This narrative review aims to provide an overview of the impact of opioid dependence and the contribution of genetics to opioid dependence. Epidemiological data demonstrate that opioid dependence is a global trend with far-reaching effects on the social, economic, and health care systems. A review of classical genetic studies of opioid use suggests significant heritability of drug use behavior,...
BACKGROUND Opioid dependence is one of the major social and psychiatric problem of society. Unfortunately there is no non opiate treatment available. For centuries man has used plants for their healing proprieties. These plants play a fundamental part in all treatment modalities, both ancient and modern. METHODS This study was conducted to find non opiate treatment for opiate withdrawal. Tota...
Opioid receptors and their endogenous peptide ligands play important roles in neurotransmission and neuromodulation in response to addictive drugs such as heroin, cocaine, and alcohol. In an earlier study, we reported that variation in the genes encoding the kappa-opioid receptor (OPRK1) and its peptide ligand (PDYN) were associated with the risk for alcoholism. We continued our investigation o...
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