the present study was carried out to determine the hypoglycemic activity of the methanolic extract and solvent fractions (n-hexane and ethyl acetate) of ruellia tuberosa in normal and alloxan-induced diabetic rabbits. optimum dose of r. tuberosa for hypoglycemic activity was determined by oral administration of the methanolic extract (me) to normal and diabetic rabbits. diabetes was induced by ...

To evaluate the optimum dose of olsalazine for maintaining remission in ulcerative colitis, 198 patients in remission for more than three months were randomly assigned to receive 0.5 g, 1.0 g, or 2.0 g/day for 12 months. A dose-ranging effect was detected in the per protocol analysis, with remission rates of 60% (0.5 g), 70% (1.0 g), and 78% (2.0 g) (p = 0.03, trend in proportions). The higher ...

We applaud Cronstein and Terkeltaub [1] on their comprehensive review of the inflammatory process of gout and its treatment. Although they allude to the fact that colchicine probably has the smallest therapeutic window of any drug used to treat acute gouty arthritis, they have suggested " In treating acute gouty arthritis colchicine is typically administered as an oral 0.6 mg dose, followed by ...