background: to explore the oral absorption of scorpion venom an elisa were designed in this study. scorpions and their venom were been used for centuries as medical treatments in traditional medicine. the oral administration of drug referred as the convenient way, as there was not any publication about gastro-intestinal absorption of scorpion venom; this experiment checked oral absorption of me...

conclusions this study demonstrated that physicochemical properties, in vitro release and rat intestine permeability were dependent upon the contents of s/c, water and oil percentage in formulations. background self-emulsifying drug delivery system is an isotropic mixture of natural or synthetic oils, non-ionic surfactants or, one or more hydrophilic solvent and co-solvents/surfactant and polym...

Desferroxamine (Desferal) is used tochelate iron in thalassemia, a disease of very high prevalence in various parts of lran. We have investigated intestinal zinc absorption in Desferal-treated rats which, in pilot experiments, showed low serum levels of both iron and zinc. Intraperitoneal administration of ten 0.5 g doses of Desferal (one injection every other day) to male rats produced sev...

desferroxamine (desferal) is used tochelate iron in thalassemia, a disease of very high prevalence in various parts of lran. we have investigated intestinal zinc absorption in desferal-treated rats which, in pilot experiments, showed low serum levels of both iron and zinc. intraperitoneal administration of ten 0.5 g doses of desferal (one injection every other day) to male rats produced severe ...

Controversy continues regarding the optimal composition of glucose electrolyte oral rehydration solutions for the treatment of acute diarrhoea. Four perfusion models (normal human jejunum, normal rat small intestine, cholera toxin treated secreting rat small intestine and rotavirus infected rat small intestine) have been developed and used to compare the efficacy of a hypotonic oral rehydration...

The aim of the present work was to confirm the usefulness of the dissolution/permeation system (D/P system) in the estimation of human oral absorption of poorly water-soluble drugs. The D/P system, which can simultaneously evaluate drug absorption processes, dissolution and permeation, can predict the oral absorption of poorly water-soluble drugs in fasted and fed humans, with a correlation bet...

A simple method for extrapolation of benzene-induced cancer risk from the inhalation to oral route is proposed. The method is based on the relative efficiency of benzene absorption across routes of exposure, especially pulmonary and gastrointestinal barriers. There exists substantial literature on pulmonary absorption in humans and a few laboratory animal species. Data on oral absorption in hum...