Background: Clinical evidence indicates the diabetes-induced impairment of osteogenesis caused by a decrease in osteoblast activity. Flavonoids can increase the differentiation and mineralization of osteoblasts in a high-glucose state. However, some flavonoids such as luteolin may have the potential to induce cytotoxicity in osteoblast-like cells. This study was performed to investigate whether...

spermatogonial stem cell (ssc) technologies provide multiple opportunities for research in the field of biotechnology and regenerative medicine. the therapeutic use of embryonic stem cells (escs) is restricted due to severe ethical and immunological concerns. therefore, we need a new pluripotent cell type. despite well-known role of germ cells in the gametogenesis, some facts apparently show th...

after maxillary expansion, a long period of retention is necessary to prevent early relapse. therefore, it is beneficial to accelerate bone formation in the expanding midpalatal suture to reduce relapse. this study was designed to evaluate the effect of dietary vitamin c on osteogenesis of rat midpalatal suture during expansion.fifty-four male wistar rats were randomly divided into three groups...

background: the problem of bone defects during treatments of bone lesions, especially cranial trauma, and also during craniotomy operations indicates isolation of osteoblasts and culturing them for filling these bone effects. methods: bone tissue specimens were obtained from 6 patients’ carvaria undergoing craniotomy surgery operations in al-zahra teaching hospital and transferred to lab. these...

objective(s):the mesenchymal stem cells (mscs) have been introduced as appropriate cells for tissue engineering and medical applications. some studies have shown that topography of materials especially physical surface characteristics and particles size could enhance adhesion and proliferation of osteoblasts. in the present research, we studied the distinction effect of 30 and 60 μg/ml of zinc ...

background: clinical evidence indicates the diabetes-induced impairment of osteogenesis caused by a decrease in osteoblast activity. flavonoids can increase the differentiation and mineralization of osteoblasts in a high-glucose state. however, some flavonoids such as luteolin may have the potential to induce cytotoxicity in osteoblast-like cells. this study was performed to investigate whether...

objective: our research attempted to show that mouse dental pulp stem cells (dpscs) with characters such as accessibility, propagation and higher proliferation rate can provide an improved approach for generate bone tissues. with the aim of finding and comparing the differentiation ability of mesenchymal stem cells derived from dpscs into osteoblast and osteoclast cells; morphological, molecula...

background: bone marrow mesenchymal stem cells (mscs) are one of the undifferentiated multipotential cell sources of human body. methods: mscs have the capacity to form a variety of cell types, especially chondrocytes and osteocytes. learning about responses of mscs to external milieu and chemical factors such as ph could recommend new approaches for preparation of suitable scaffolds for bone a...

The osteoblast is the bone-forming cell. The molecular basis of osteoblast-specific gene expression and differentiation is unknown. We previously identified an osteoblast-specific cis-acting element, termed OSE2, in the Osteocalcin promoter. We have now cloned the cDNA encoding Osf2/Cbfa1, the protein that binds to OSE2. Osf2/Cbfa1 expression is initiated in the mesenchymal condensations of the...

Indian hedgehog (Ihh) signaling is indispensable for osteoblast differentiation during endochondral bone development in the mouse embryo. We have previously shown that the Gli2 transcription activator critically mediates Ihh function in osteoblastogenesis. To explore the possibility that activation of Hedgehog (Hh) signaling may enhance bone formation, we generated mice that expressed a constit...