OBJECTIVE Umbilical mesenchymal stem cells (UMSCs) is one of most popular regenerative medical source of bone replacement therapy in both clinical and scientific researches. However, it is still low effective to induce the osteogenesis of hUMSCs. In this study, we aimed to elucidate the roles of DNA methyltransferase 3B (DNMT3B) in the osteogenesis of hUMSCs. MATERIALS AND METHODS Knockdown D...

Learning Objectives: After studying this article, the participant should be able to: 1. Review the biomechanical principles and pertinent cellular and molecular biology of distraction osteogenesis of the craniofacial skeleton. 2. Describe the clinical indications and applications of distraction osteogenesis of the craniofacial skeleton. 3. Describe maxillary, mandibular, midface, and calvarial ...

objectives: the purpose of this study was to evaluate whether intra-canal application of controlled direct electric current (dec) could accelerate the amount of orthodontic tooth movement (otm) in young adult mixed breed dogs. methods: fourth premolars of both jaws of five young adult mixed breed dogs were divided into two groups of control and experimental groups. orthodontic force was applied...

Distraction osteogenesis is a powerful technique for creating new bone during significant lengthening of the mandible without the need for bone grafting and associated donor site morbidity. The majority of clinical applications of mandibular lengthening with distraction osteogenesis techniques reported in the literature are in growing patients.1-8 For the purposes of this article, an adult pati...

Osteogenesis imperfecta is a genetic disorder of type I collagen. Although multiple genotypes and phenotypes are associated with osteogenesis imperfecta, approximately 90% of the mutations are in the COL1A1 and COL1A2 genes. Osteogenesis imperfecta is characterized by bone fragility. Patients typically have multiple fractures or limb deformity; however, the spine can also be affected. Spinal ma...

Osteogenesis imperfecta is a disease characterized by increased fragility of the bones which are easily fractured by slight trauma. Patients suffering from this disorder usually have blue sclerae and flaccid ligaments; some of them become deaf later in life. Scattered reports of this disorder date back at least to 1678 (quoted by Seedorff in 1949). Vrolik (1849) described the disease in the new...

purpose: congenital third nerve palsy was generally thought to exist in isolation without associated abnormalities. in this report, we present a case of congenital third nerve palsy in osteogenesis imperfecta. methods: a 6-month-old girl with osteogenesis imperfceta presented with ptosis and large incomitant exotropia in left eye (le) at birth. ocular examination revealed total third nerve pals...

limb lengthening by distraction osteogenesis was fi   fi key words: biomechanics, callostasis, distraction histogenesis, distraction osteogenesis,mechanical strain, osteodistraction, vector   ed the physiologic and mechanical factors governing   successful regeneration of bone formation. distraction osteogenesis is a new variation of more traditional orthognathic surgical procedure for the corr...

bone is formed through the processes of endochondral and intramembranous ossification. in endochondral ossification primary mesenchymal cells differentiate to chondrocytes and then are progressively substituted by bone, while in intramembranous ossification mesenchymal stem cells (mscs) differentiate directly into osteoblasts to form bone. the steps of osteogenic proliferation, differentiation,...