Background: Cytokines, chemokines, and chemokine receptors regulate the proliferation and survival of tumor cells, angiogenesis, and metastasis to other organs. This network of ligands and receptors has been used in molecular targeting of cancer. Methods: We compared the mRNA expression of CXCR3, CXCL-10, CXCR4, CXCL-12, IL-4, and IL-10 in tissues of benign and malignant ovarian tumors by qRT-P...

background: ovarian cancer is the most common cause of cancer death worldwide. incidence of ovarian cancer is more common in postmenopausal women. premenopausal onset is rare and the present study described two cases of ovarian clear cell tumors in young women. case presentation: the patients presented with pelvic mass which was confirmed by sonography and laparotomy and final diagnosis was mad...

objective(s): juglone is isolated from many species of the juglandaceae family and used as an anti-viral, anti-bacterial, and anti-tumor therapeutic. here, we evaluated juglone-induced antitumor effect in ovarian cancer skov3 cells. materials and methods: mtt assay was performed to examine juglone anti-proliferative effect. cell cycle and apoptosis were studied using flow cytometry in juglone-tr...

background: bleomycin (blm) is an anti-cancer drug widely used in the treatment of cancer. blm causes several side effects related to dna and cellular damage. the aim of this study was investigated the effects of tea polyphenol epicatechin on anti-proliferative effects induced by bleomycin in human normal skin and human ovarian cancer cells.materials and methods: human ovarian cancer cell (skov...

background: anti-angiogenic therapy is a crucial step in cancer treatment. the discovery of new anti-angiogenic compounds from marine organisms has become an attractive concept in anti-cancer therapy. because little data correlated to the pro- and anti-angiogenic efficacies of ophiuroidea, which include brittle star, the current study was designed to explore the anti-angiogenic potential of bri...

Background and Objective: It is well known that menstrual period and ovarian function are affected by chemotherapy. Although breast cancer is the most common cause of chemotherapy in women and ovarian hormones have very important direct and indirect effects on overall survival, disease-free survival, and...

Background: It seems that Vinca. herbacea has an anti-tumor effect. Here, the immunotherapeutic effect of this compound is assessed against human ovarian cancer (SKOV3) cells because of the high incidence of this tumor in women. Materials and Methods: The cytotoxic activity of V. herbacea extract against human ovarian cancer (SKOV3) cells was determined by MTT assay. The apoptosis-inducing pote...

background : the present study aimed to investigate the rate and time of ovarian function restoration in breast cancer patients between 40 and 60 years of age who were in menopause (biochemically documented) and received letrozole after chemotherapy. we intended to further clarify the management strategy for breast cancer patients with different menopausal status. methods : we prospectively mea...