The preparation, for the first time, of the deprotonated complexes of oxamic acid with Ce(III), Pr(III), Nd(III), Sm(III), Eu(III), Dy(III), Ho(III ) and Yb(III ) is reported. Properties, analytical results, conductometric measurements, magnetic moments and spectral data (IR and diffuse reflectance spectra) are discussed in terms of possible structural types and the nature of the bonding. Oxami...

A number of derivatives of Sepharose 4B gels were prepared containing tyramine, -Gly -Gly -Tyr and the tetrapeptide, Thr (But)-Phe-Pro-Tyr -. A specific inhibitor of sialidase, p-diazo-phenyl oxamic acid, was also coupled to these phenolsubstituted Sepharose gels. The effectiveness of these gels to purify sialidase by "affinity" chromatography was examined. The sialidase from Vibrio cholerae wa...

amide-iminol tautomerism was studied for ionized oxamic acid (oa+•) in the gas phase using thedft method with the ub3lyp functional and various basis sets {6-31++g(d,p), 6-311+g(d,p), and augcc-pvdz}. among twenty tautomers-rotamers possible for oa+•, eleven isomers were found to bethermodynamically stable. similarly as for the neutral molecule, ionization (oa → oa+• + e) favors theamidization ...

A membrane-bound sialidase was isolated from blood stream (BS) Trypanosoma evansi partially purified and characterized. The enzyme is a glycosyl phosphatidyl inositol (GPI) membrane anchored protein. It was solubilized from T. evansi cells recovered from infected camel blood by detergent treatment with Triton CF 54 and partially purified by a series of chromatography steps. The enzyme was optim...

Many cancer cells rely on aerobic glycolysis for energy production and targeting of this pathway is a potential strategy to inhibit cancer cell growth. In this study, inhibition of five glycolysis pathway molecules (GLUT1, HKII, PFKFB3, PDHK1 and LDH) using 9 inhibitors (Phloretin, Quercetin, STF31, WZB117, 3PO, 3-bromopyruvate, Dichloroacetate, Oxamic acid, NHI-1) was investigated in panels of...

It is now well known that tumor tissues, either in the form of solid tumors or as ascites cells, have a high rate of aerobic and anaerobic glycolysis. A theory on the origin of the tumor cell as proposed by Warburg (1,2) states that a normal cell becomes malignant as the result of impairment to its respiratory processes. Warburg has stated (1, 2) that in order for these cells to survive they mu...

Amide-iminol tautomerism was studied for ionized oxamic acid (OA+•) in the gas phase using theDFT method with the UB3LYP functional and various basis sets {6-31++G(d,p), 6-311+G(d,p), and augcc-pVDZ}. Among twenty tautomers-rotamers possible for OA+•, eleven isomers were found to bethermodynamically stable. Similarly as for the neutral molecule, ionization (OA → OA+• + e) favors theamidization ...