Oxidative stress is increasingly implicated as a co-factor of tissue injury in inflammatory/demyelinating disorders of the central nervous system (CNS), such as multiple sclerosis (MS). While rodent experimental autoimmune encephalomyelitis (EAE) models diverge from human demyelinating disorders with respect to limited oxidative injury, we observed that in a non-human primate (NHP) model for MS...

Objective(s):Therapies with high levels of oxygen are commonly used in the management of critical care. However, prolonged exposure to hyperoxia can cause acute lung injury. Although oxidative stress and inflammation are purported to play an important role in the pathogenesis of acute lung injury, the exact mechanisms are still less known in the hyperoxic acute lung injury (HALI).   Materials ...

Mitochondrial dysfunction is the most prominent source of oxidative stress in acute and chronic kidney disease. NLRX1 is a receptor of the innate immune system that is ubiquitously expressed and localized in mitochondria. We investigated whether NLRX1 may act at the interface of metabolism and innate immunity in a model of oxidative stress. Using a chimeric mouse model for renal ischemia-reperf...

Benzene is a volatile chemical implicated in leukemia and hepatic injury through oxidative stress-mediated mechanism. Linalool naturally small molecular monoterpene with proven antioxidant pro...

Purpose: To investigate the biological functions of miR-423-5p in a mouse model with lipopolysaccharide (LPS)-induced acute liver injury.Methods: Sixty male C57BL/6 mice were randomized into control group (n = 20), LPS 20) and + mimic 20). The levels pro-inflammatory cytokines apoptosisassociated proteins tissues determined. Finally, survival was recorded within 7 days after injection LPS.Resul...

background: testicular torsion and detorsion causes reperfusion injury which damages the testicular tissue and affects the quality of sperm. deterioration in the quality of sperm worldwide is the recent scenario and one of its reasons is testicular ischemic/ reperfusion (ir) injury. therefore the present study aims at producing new drugs for the treatment of testicular ir injury. methods: 42 an...

acute renal damage mainly develops following toxic or ischemic insults and is defined as acute. these damages have largely been attributed to oxidative stress. recently much attention has been directed toward decreased renal tubular cell regeneration during tubular cell injury. antioxidants have recently been the focus of researchers and scientists for prevention and treatment of various oxidat...