This study explored the effects of a single administration of flunixin meglumine (acting as a non-steroidal antiinflammatory drug) and oxytetracycline combination on the reproductive performance of cows diagnosed with subclinical endometritis during the postpartum period. Cows aged 3 to 9 at 40 to 60 days postpartum were studied. Endometrial samples were collected from cows that had a uterine c...

We examined how a dietary supplement affects the prevalence of antibiotic-resistant Escherichia coli on a dairy farm in Washington State. Between 2001 and 2004 the prevalence of fecal E. coli strains resistant to streptomycin, sulfadiazine, and tetracycline (SSuT strains) declined from 59.2% to 26.1% in the calf population. In 2003 the dairy discontinued use of a dietary supplement, and we hypo...

Antimicrobials used in salmon aquaculture pass into the marine environment. This could have negative impacts on marine environmental biodiversity, and on terrestrial animal and human health as a result of selection for bacteria containing antimicrobial resistance genes. We therefore measured the numbers of culturable bacteria and antimicrobial-resistant bacteria in marine sediments in the Calbu...

16 Routine application of antimicrobials is the current treatment of choice for rainbow trout 17 fry syndrome (RTFS) or bacterial coldwater disease (BCWD) caused by Flavobacterium 18 psychrophilum. In this study, the antimicrobial susceptibilities of 133 F. psychrophilum 19 isolates, 118 of which were from the UK, were evaluated by broth microdilution and disc 20 diffusion methods following VET...

In the present study the feed and water consumption and pharmacokinetic parameters of orally administered oxytetracycline were compared in clinically healthy pigs and in the same pigs following a challenge with Actinobacillus (Haemophilus) pleuropneumoniae toxins. Endobronchial challenge with A. pleuropneumniae toxins was accompanied by anorexia, increased lassitude, labored breathing, fever, a...

The paper aimed to study the toxic effects of the degradation products of oxytetracycline and chlortetracycline, such as, α-apo-oxytetracycline (α-apo-OTC), β-apo-oxytetracycline (β-apo-OTC), anhydro-chlortetracycline (ACTC) and 4epi-anhydro-chlortetracycline (EACTC) on rats. Male rats received oral doses of 10 mg/kg body weight/day of either α-apo-OTC, β-apo-OTC, ACTC or EACTC for 90 d. At the...

The 387kb linear plasmid pPZG101 of Streptomyces rimosus R6 can integrate into the chromosome or form a prime plasmid carrying the oxytetracycline biosynthesis cluster. The integration of plasmid pPZG101 into the linear chromosome of S. rimosus R6-501 in mutant MV25 was shown to be due to a single cross-over at a 4 bp common sequence. pPZG101 had integrated into a 250 kb DNA sequence that was r...

Introduction Infectious bovine keratoconjunctivitis (IBK) is caused by a Gram-negative bacterium, Moraxella bovis. It is characterised by acute contagious ophthalmia and it spreads rapidly among cattle in a herd. M. bovis is generally present on the mucous membranes of healthy animals and is considered to be an opportunistic pathogen (Quinn et al., 1994; Gyles and Thoen, 1993). The bacterium is...

OBJECTIVES To determine the prevalence of antibiotic-resistant faecal Escherichia coli from adult volunteers from urban (U) areas in Kenya, Mexico, Peru and the Philippines, and non-urban (NU) locations in Curacao, Mexico, Venezuela, Ghana, Zimbabwe and the Philippines. METHODS Faecal samples of adult volunteers (n=1290) were analysed in one laboratory for the presence of antimicrobial-resist...