Oxytetracycline is a polyketide antibiotic made by Streptomyces rimosus. From DNA sequencing, the gene product of otcD1 is deduced to function as a bifunctional cyclase/aromatase involved in ring closure of the polyketide backbone. Although otcD1 is contiguous with the ketoreductase gene, they are located an unusually large distance from the genes encoding the "minimal polyketide synthase" of t...

Oxytetracycline (200 mg/kg body weight,ip) was administered in 0.5 ml of sterile physiological saline for 15 days, resulting in significant increase in serum urea, creatinine and reduction in creatinine clearance. A significant increase in lipid peroxidation markers (TBARS and lipid hydroperoxides) and, decrease in enzymic antioxidants (superoxide dismutase,catalase,glutathione peroxidase and g...

BACKGROUND Chemical pleurodesis is widely recommended in the treatment of refractory pleural effusion or pulmonary air leak of different etiologies. Although several agents have been used, many questions have remained unanswered about their toxicity. Talc is the most commonly used agent for the treatment, with rare, serious complications reported. Oxytetracycline pleurodesis in clinical practic...

Oxytetracycline is used to treat various diseases in cattle. However, its use may be associated with unacceptable residue levels in food. Oxytetracycline residues in tissues from indigenous cattle were determined in a cross-sectional study conducted in the Kilosa district, Tanzania, between November 2012 and April 2013. A total of 60 tissue samples, including muscle, liver and kidney, were coll...

Fifty buffaloes(healthy and mastitic udders) were milked aseptically from separate regions of Kaliobia governorate .California mastitis test (CMT) and bacteriological examination were achieved .Upon susceptibility testing (12) antibiotics were used to explain different susceptibility patterns of the isolated bacteria The objective of this study was the detection of oxytetracycline, sulphadimidi...

introduction: antibiotics have the potential to adversely affect the microbial community. for anaerobic digestion, a sufficient methanogenic population needs to be preserved in the system. the main aim of this study was determination of inhibitory concentration of oxytetracycline on methanogenic bacteria. methods: a 120 ml jacketed bioreactor with a 90 ml working volume was inoculated granular ...

production of oxytetracycline by an isolated strain of streptomyces rimosus from iranian soil was investigated using a special fermentation medium. a comparative study was performed with standard strain ptcc 1144 using the following parameters optimum growth conditions with respect to time, ph, and different amounts of corn steep liquor. surprisingly, the production yield of the wild strain was...

During a previous study1 we had used oxytetracycline in conjunction with other antituberculosis drugs for the treatment of tuberculous infection. This study proved thai oxytetracycline may be employed to great advantage as an ancillary drug along with isoniazid, streptomycin or viomycin. While using oxytetracycline in this way, and over a considerable period of time, we were impressed with its ...

Tetracycline and related compounds are used extensively as broad spectrum antibiotics in the treatment of bacterial infections in ruminants. Tetracycline may cause acute pancreatitis which may result in increased serum amylase activity. However, it has been shown that administration of oxytetracycline in human results in decrease serum amylase activity. In this study changes in serum amylase ac...

The use of oxytetracycline for preventing and controlling bacterial pathogens in salmon farming is frequent in Chile, yet no studies have been performed to evaluate the ecological impact of its intensive and prolonged use. In this work, the frequency of oxytetracycline-resistant bacteria from water, pelletized feed and fingerlings from four Chilean freshwater Atlantic salmon farms, as well as t...