A long-acting oxytetracycline in polyethylene glycol (PEG) was evaluated in a single dose study at 6.6 mg/kg IV and IM and in a long-term dose study at 20 mg/kg IM q 72 h. Pharmacokinetic results were typical for long-acting oxytetracycline formulation. The intramuscular injections caused local irritation, but oxytetracycline-PEG did not alter microbial flora or cause adverse gastrointestinal e...

Serum oxytetracycline pharmacokinetics were studied in 18 African elephant (Loxodonta africana) calves. Each elephant received separate injections of oxytetracycline at approximately 18 mg/kg i.m. and 8 mg/kg i.v. in a cross-over study. Blood samples were drawn at 0, 24, 48, 72, and 96 hr postinjection. An additional sample was drawn 110 hr before the animals were reinjected in the cross-over s...

The pharmacokinetics of conventional and long-acting oxytetracycline (OTC) formulation were evaluated in sheep at a single dosage of 20 mg-kg-1 body weight (bw). Conventional formulation was injected by intravenous (IV) route and long-acting formulation of oxytetracycline was administered by intramuscular (IM) route. Then blood samples were taken at 0.25, 0.5, 1, 2, 4, 8, 12, 24, 36, 48, 60, 72...

The in vitro activities of enrofloxacin, florfenicol, oxytetracycline and spiramycin were determined against field isolates of Mycoplasma mycoides mycoides large colony (MmmLC) by means of the broth microdilution technique. The minimum inhibitory concentrations (MICs) of these antimicrobial drugs were determined for a representative number of 10 isolates and 1 type strain. The susceptibility of...

Production of oxytetracycline by Streptomyces rimosus in several chemically defined media containing graded concentrations of inorganic phosphorus was studied in shake flasks. Although high levels of inorganic phosphate have been reported to inhibit oxytetracycline formation, this study indicated that composition of the medium is an important factor in determining whether antibiotic production ...

The aim of this study was to investigate the presence of tetracycline and oxytetracycline resistance determinants in Bacillus cereus strains isolated from honey samples. Of a total of 77 isolates analyzed, 30 (39%) exhibited resistance to tetracyclines according to the results of a disk diffusion method. Resistant strains (n=30) were screened by PCR for the presence of the resistant determinant...

Oxytetracycline, one of the tetracycline family, is a broadspectrum antibiotic produced by different species of Streptenryces, namely Streptomyees rimosus, Streptonryces capuensis, Streptomyces henetus, and Struptomyces platensis (Finlay et al,i)), The antibiotic is active on Gram-pesitive and negative bacteria, spirochetes, rickettsiae, nd some viruses, Many workers2"i4) have studied factors a...

From a genetic standpoint, Streptomyces rimosus is arguably the best-characterized industrial streptomycete as the producer of oxytetracycline and other tetracycline antibiotics. Although resistance to these antibiotics has reduced their clinical use in recent years, tetracyclines have an increasing role in the treatment of emerging infections and noninfective diseases. Procedures for in vivo a...

The role of immune system is to sustain host defense mechanisms and maintain homeostasis. The immune system maintains a constant surveillance against invading pathogenic microorganisms, Immunomodulation may involve either an increase in the magnitude of immune response i.e. immunostimulation or a decrease in the magnitude of the immune response i.e. immunosuppression. Long acting oxytetracyclin...