Split immunological tolerance refers to states in which an individual is capable of mounting certain types of immune responses to a particular antigenic challenge, but is tolerant of the same antigen in other compartments of the immune system. This concept is applicable to the immunological relationship between mother and fetus, and particularly relevant in equine pregnancy. In pregnant mares, ...

N-acetyl-L-cysteine (NAC) has been proposed as an additional therapeutic agent for AIDS patients because it reduces human immunodeficiency virus type 1 (HIV-1) replication in stimulated CD4+ lymphocytes, and it ameliorates immunological reactivity. In a randomized, 180-day, double-blind, placebo-controlled trial performed with HIV-infected patients classified as A2 and A3 according to the crite...

A number of cases of unexplained (idiopathic) recurrent spontaneous abortions may be attributable to immunological mechanisms. Several lines of evidence indicate that some immunocompetent effector cell populations play an important role in the pathogenesis of unexplained miscarriages. However a suitable method is lacking for defining an existing immunological background of recurrent spontaneous...

This prospective study used longitudinal, multi-reporter data to examine the influence of parents' marital relationship functioning on subsequent adolescent romantic relationships. Consistent with Bryant and Conger's (2002) model for the Development of Early Adult Romantic Relationships (DEARR), we found that interactional styles, more specifically paternal aggression and satisfaction, exhibite...

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Whereas approximately half of metastatic melanoma patients benefit from combined immune checkpoint inhibition targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and Programmed cell death 1 (PD-1), for those who do not respond, further strategies treatment options need to be developed. Thus, focus is turning the use chimeric antigen receptor (CAR) T cells, a novel therapy that has ye...

Abstract Background and aims There is a growing need for biomarkers of inflammation to monitor predict therapeutic outcome in Crohn’s disease (CD) patients. We aimed evaluate whether the level circulating blood cells, expressed as ratios (NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ELR, eosinophil-to-lymphocyte ratio ENLR, eosinophil*neutrophil-to-lymphocyte ratio), could b...

Background Central immunity components especially microglia in dementia have been well studied and corresponding immunotherapy gradually caught the attention. However, few studies focused on peripheral dementia. Method To address issue, we examined longitudinal association between incident markers encompassing immune cell counts, their derived ratios including neutrophil-to-lymphocyte ratio (NL...