Pancreatic cancer (PC) accumulates multiple genetic mutations, including activating KRAS mutations and inactivating TP53, SMAD4 and CDKN2A mutations, during progression. The combination of mutant KRAS with a single inactivating TP53, SMAD4 or CDKN2A mutation in genetically engineered mouse models (GEMMs) showed that these mutations exert different synergistic effects in PC. However, the effect ...

BACKGROUND Roughly 40% of germinal mutations in melanoma families (MF) affect p16(INK4a) and p14(ARF). We investigated the association between INK4/ARF alterations and the occurrence of pancreatic cancer in MF and in sporadic pancreatic cancer (SPC) patients. PATIENTS AND METHODS Forty-nine MF, 66 SPC cases and 54 controls were enrolled. The INK4/ARF locus was screened. RESULTS As compared ...

BACKGROUND Pachyonychia congenita (PC) is a genodermatosis caused by mutations in 1 of 4 known keratin genes, including KRT6A, KRT6B, KRT16, or KRT17. The most common mode of inheritance is autosomal dominant. Families with an affected parent are routinely counseled about the 50% transmission risk to each offspring. In some cases, families with a rare disorder like PC can initially present with...

Recently we have described (1) an IgM antibody that has the unique property of specific self binding. The 11 E7-1 hybridoma was isolated by fusion with a nu/nu BALE/c mouse immunized with TEPC 15 myeloma protein (T15). The mAb 11 E7-1 binds to PC, to insolubilized T15, and to 11E7-1 itself. Thebinding is specifically inhibited by free PC and PC analogs . Thus, this antibody has a dual specifici...

Valproic Acid for TBI Engagement in Meaningful Activities Interpreters’ Challenges EOL Discussions Goals and Preferences of Older Adults ACP Patients with Cirrhosis Children's Regrets After Sibling Death Psychiatric Symptomology COVID Rave Reviews Administration Cases Traumatic Brain Injury Background: brain injury (TBI) remains a major source morbidity mortality the US worldwide.1,2 Can valpro...