نتایج جستجو برای: pc mutation

تعداد نتایج: 331855  

Journal: :Journal of the Robotics Society of Japan 1998

Journal: :The Biochemical journal 2003
Michiel H M van der Sanden Martin Houweling Lambert M G van Golde Arie B Vaandrager

Inhibition of de novo synthesis of phosphatidylcholine (PC) by some anti-cancer drugs such as hexadecylphosphocholine leads to apoptosis in various cell lines. Likewise, in MT58, a mutant Chinese hamster ovary (CHO) cell line containing a thermo-sensitive mutation in CTP:phosphocholine cytidylyltransferase (CT), an important regulatory enzyme in the CDP-choline pathway, inhibition of PC synthes...

Journal: :iranian journal of nuclear medicine 2011
seyed pezhman shirmardi mostafa erfani mohammad mazidi

introduction: bombesin is a 14-aminoacid peptide isolated from frog skin. the mammalian counterparts of the frog peptide are neuromedin b (nmb) and gastrin-releasing peptide (grp). bombesin (bbn) is a peptide showing high affinity for the gastrin releasing peptide receptor (grpr). prostate, small cell lung cancer, breast, gastric, and colon cancers are known to over express receptors to bombesi...

2007
Volker Nannen A. E. Eiben

The main objective of this paper is to present and evaluate a method that helps to calibrate the parameters of an evolutionary algorithm in a systematic and semi-automated manner. The method for Relevance Estimation and Value Calibration of EA parameters (REVAC) is empirically evaluated in two different ways. First, we use abstract test cases reflecting the typical properties of EA parameter sp...

2011
S. A. Díaz A. M. Toscani D. J. Arndt-Jovin T. M. Jovin E. A. Jares-Erijman

We recently reported a novel surface architecture for the generation of biocompatible and stable photoswitchable quantum dots (psQDs). The system is based on Förster Resonance Energy Transfer (FRET) from a QD donor to diheteroarylethenes photochromic (PC) acceptors (pcFRET). The PC molecules are linked to an amphiphilic polymer that self-assembles, creating an interior lipophilic space, in whic...

Journal: :Behavior Research Methods, Instruments, & Computers 1984

Journal: :Rinsho shinkeigaku = Clinical neurology 2010
Kei Watase Kinya Ishikawa Hidehiro Mizusawa

Spinocerebellar ataxia type 6 (SCA6) is one of the common dominantly inherited ataxias in Japan, featuring late-onset ataxia and selective Purkinje cell (PC) degeneration. Molecular pathogenesis of SCA6 has been attracting considerable attention since it is caused by small CAG repeat expansions within the Ca(v)2.1 voltage-gated Ca(++) channel gene (CACNA1A). During the past 9 years, efforts hav...

Journal: :Journal of biomolecular structure & dynamics 2008
Ali Mokdad Alan D Frankel

The existence and identity of non-Watson-Crick base pairs (bps) within RNA bulges, internal loops, and hairpin loops cannot reliably be predicted by existing algorithms. We have developed the Isfold (Isosteric Folding) program as a tool to examine patterns of nucleotide substitutions from sequence alignments or mutation experiments and identify plausible bp interactions. We infer these interact...

Journal: :Neuron 2012
Hisako Nakayama Taisuke Miyazaki Kazuo Kitamura Kouichi Hashimoto Yuchio Yanagawa Kunihiko Obata Kenji Sakimura Masahiko Watanabe Masanobu Kano

Functional neural circuit formation during development involves massive elimination of redundant synapses. In the cerebellum, one-to-one connection from excitatory climbing fiber (CF) to Purkinje cell (PC) is established by elimination of early-formed surplus CFs. This process depends on glutamatergic excitatory inputs, but contribution of GABAergic transmission remains unclear. Here, we demons...

Journal: :Head & neck 2009
Vladimir Vinarsky Robert L Fine Adel Assaad Ying Qian John A Chabot Gloria H Su Harold Frucht

BACKGROUND Germline mutations at the INK4a/p16 locus are implicated in several human cancer syndromes, including familial atypical multiple mole melanoma (FAMMM) syndrome, FAMMM-pancreatic cancer (FAMMM-PC) syndrome, and in familial head and neck cancer syndrome. METHODS We present an individual with a family history of melanoma and pancreatic cancer who had multiple dysplastic nevi, squamous...

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