نتایج جستجو برای: pc mutation

تعداد نتایج: 331855  

Journal: :Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2009
Jennifer LaFemina Penelope A Roberts Yin P Hung James F Gusella Dushyant Sahani Carlos Fernández-del Castillo Andrew L Warshaw Sarah P Thayer

BACKGROUND/AIMS Hereditary pancreatic cancer comprises about 10% of pancreatic cancer cases. Multiple causative mutations have been identified. Here we describe a pancreatitis/pancreatic cancer (P/PC) family, which demonstrates pancreatitis and pancreatic cancer resulting from an uncharacterized mutation. METHODS Family members completed evaluations to determine signs of mutation status. Sele...

2017
Frances J D Smith W H Irwin McLean

Dear Editor, Pachyonychia congenita (PC) is an ultra-rare hereditary skin disorder primarily characterized by severe, painful and highly debilitating plantar keratoderma, variable hypertrophic nail dystrophy, epidermal cysts, leukokeratosis and other features. PC is caused by heterozygous dominant-negative mutations in any one of five keratin genes, KRT6A, KRT6B, KRT6C, KRT16 or KRT17 (encoding...

Journal: :Pediatric dermatology 2016
Charlotte E Forrest Genevieve Casey Dylan A Mordaunt Elizabeth M Thompson Lynne Gordon

BACKGROUND Pachyonychia congenita (PC) is a rare inherited disorder of keratinization characterised by hypertrophic nail dystrophy, painful palmoplantar blisters, cysts, follicular hyperkeratosis and oral leukokeratosis. It is associated with mutations in five differentiation-specific keratin genes, KRT6A, KRT6B, KRT6C, KRT16, or KRT17. OBJECTIVES Living with Pachyonychia Congenita can be iso...

Journal: :Journal of virology 2007
Richard A Heipertz Thomas G Miller Colleen M Kelley William E Delaney Stephen A Locarnini Harriet C Isom

Understanding the consequences of mutation in the hepatitis B virus (HBV) genome on HBV replication is critical for treating chronic HBV infection. In this study, HBV replication in HepG2 cells initiated by transduction with precore (PC), rtM204I, and wild-type (wt) HBV recombinant baculoviruses was compared. The pattern and magnitude of HBV replication initiated by the PC HBV recombinant bacul...

Journal: :Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2013
Ewa Wypasek Anetta Undas

Protein C (PC) and protein S (PS) are vitamin K-dependent glycoproteins, that act as natural anticoagulants. The proteolytic activation of PC by thrombin occurs on the surface of endothelial cells and involves thrombomodulin and endothelial PC receptor. In the presence of PS, phospholipids and calcium, activated PC (APC) inactivates membrane bound factors V (FVa) and FVIIIa by their cleavage at...

2014
Apilak Wutthisathapornchai Tuangtong Vongpipatana Sureeporn Muangsawat Thirajit Boonsaen Michael J. MacDonald Sarawut Jitrapakdee

Pyruvate carboxylase (PC) is an anaplerotic enzyme that regulates glucose-induced insulin secretion in pancreatic islets. Dysregulation of its expression is associated with type 2 diabetes. Herein we describe the molecular mechanism underlying the glucose-mediated transcriptional regulation of the PC gene. Incubation of the rat insulin cell line INS-1 832/13 with glucose resulted in a 2-fold in...

Journal: :Journal of immunology 2003
Gregory D Wiens McKay Brown Marvin B Rittenberg

Phosphocholine (PC) is a naturally occurring Ag common to many pathogenic microorganisms. Early in the primary response to PC conjugated to keyhole limpet hemocyanin (KLH), T15 Id(+) Abs constitute >90% of the serum Ig in BALB/c mice. During the late primary and memory response to PC-protein, a shift in the repertoire occurs and T15 Id(+) Abs lose dominance. In this study, we use immunohistoche...

Journal: :hepatitis monthly 0
sima besharat liver and pancreatobiliary diseases research center, digestive disease research institute, tehran university of medical sciences, tehran, ir iran; golestan research center of gastroentrology and hepatology, golestan university of medical sciences, gorgan, ir iran hossein poustchi liver and pancreatobiliary diseases research center, digestive disease research institute, tehran university of medical sciences, tehran, ir iran; liver and pancreatobiliary diseases research center, digestive diseases research institute, tehran university of medical sciences, north kargar ave., shariati hospital, p.o. box: 14117-13135, tehran, ir iran. tel: +98-2182415204, fax: +98-21 82415400 ashraf mohamadkhani liver and pancreatobiliary diseases research center, digestive disease research institute, tehran university of medical sciences, tehran, ir iran aezam katoonizadeh liver and pancreatobiliary diseases research center, digestive disease research institute, tehran university of medical sciences, tehran, ir iran abdolvahab moradi golestan research center of gastroentrology and hepatology, golestan university of medical sciences, gorgan, ir iran gholamreza roshandel liver and pancreatobiliary diseases research center, digestive disease research institute, tehran university of medical sciences, tehran, ir iran; golestan research center of gastroentrology and hepatology, golestan university of medical sciences, gorgan, ir iran

background although certain hbv mutations are known to affect the expression of hepatitis e antigen, their association with hbv viral level or clinical outcomes is less clear. objectives we evaluated associations between different mutations in the basal core promoter (bcp) and pre-core (pc) regions of hbv genome and subsequent changes in hbv viral dna level over seven years in a population of u...

ژورنال: :پژوهش های بالینی دامپزشکی 0
میترا صالحی گروه میکروبیولوژی، دانشکده علوم زیستی، واحدتهران شمال، دانشگاه آزاداسلامی، تهران، ایران سمیه محمدی دانشجوی کارشناسی ارشد میکروبیولوژی، گروه میکروبیولوژی، دانشکده علوم زیستی، واحد تهران شمال، دانشگاه آزاد اسلامی، تهران، ایران

سالمونلا باکتری گرم منفی میباشد که قادر به ایجاد عفونت در طیف وسیعی از و حیوانات مزرعه مانند گاو، مرغ، خوک، خزندگان و انسان است که از طریق مواد غذایی آلوده قابل انتقال به انسان میباشد. در این مطالعه از روش  pcrبرای تشخیص سالمونلا در روده مرغ استفاده شد. در این پژوهش،  100نمونه روده مرغ بعد کشتار از مرغداریهای اطراف شهرستان ساری تهیه گردید. همه نمونهها با استفاده از آزمایشهای میکروبی و بیوشیمیای...

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