The surgical indications in 770 patients with Crohn's disease undergoing intestinal resection at The Mount Sinai Hospital from 1960-83 have been reviewed. Surgical indications were divided into two principal categories: 375 cases with perforating indications and 395 cases non-perforating. Among 292 patients who underwent second operations for recurrent Crohn's disease, the indications for secon...

Perforating disorders in patients with chronic renal failure (CRF), diabetes mellitus (DM), or both, may resemble any or all of the four classic cutaneous perforating disorders. However, due to the highly variable and overlapping histologic appearance of the lesions in patients with CRF, DM, or both, it may be useful to categorized these lesions as a distinct, yet encompassing process, termed b...

ARPC: acquired reactive perforating collagenosis RPC: reactive perforating collagenosis INTRODUCTION Acquired reactive perforating collagenosis (ARPC) is a type of perforating disorder that is often associated with underlying systemic diseases, such as diabetes mellitus, renal failure, or malignancy. Giant variants of ARPC may reach up to 2 cm in size and have been reported in only a handful of...

Acquired reactive perforating collagenosis is a perforating dermatosis usually associated with different systemic diseases, mainly diabetes mellitus and/or chronic renal insufficiency. Different therapies have been tried but treatment is not standardized yet and remains a challenge. In the last few years, allopurinol has been reported as a good therapeutic option for acquired reactive perforati...

Diabetes mellitus increases the risk of cerebrovascular disease, the effects of hypercapnia on CBF (cerebral blood flow) and cerebrovascular reactivity during diabetes are still inconsistent. Here, we have established a new microangiographic technique using synchrotron radiation (SPring-8, Japan), which enabled us to visualize rat cerebral vessels with high spatial resolution in real time. The ...

A perforating vein can become incompetent due to hemodynamic or morphologic causes. Until recently all perforating veins with a diameter exceeding 3 mm at ultrasound exam were considered incontinent(1). Since introduction of duplex doppler and color doppler investigations this hypothesis was temperated because the dilatation of one or more perforating veins was usually observed in chronic venou...

APD: acquired perforating dermatosis CRF: chronic renal failure DM: diabetes mellitus EPS: elastosis perforans serpiginosa ESRD: end-stage renal disease RPC: reactive perforating collagenosis INTRODUCTION Perforating dermatosis is a heterogeneous group of disorders characterized by transepidermal elimination of dermal components such as collagen, elastin, or fibrin. Acquired perforating dermato...

A 59-year-old man with chronic renal failure and diabetes mellitus presented with pruritic crusted lesions which histologically were perforating disorders, showing features of both Kyrle disease and acquired perforating collagenosis. The mechanisms of transepidermal elimination and the classification of perforating disorders are briefly discussed. Additionally, we question the concept of perfor...

OBJECTIVE In microvascular decompression for hemifacial spasm, the perforating branches around the facial nerve root exit zone occasionally complicate facial nerve decompression. In this context, the vertebrobasilar configuration was retrospectively correlated with the perforating branches. METHODS Based on vertebral angiography, magnetic resonance angiography, and three dimensional computed ...