Imatinib is an orally administered tyrosine kinase inhibitor which inhibits the Bcr-Abl protein-tyrosine kinase with high selectivity. Imatinib is rapidly absorbed from the gut, after oral intake and has an almost absolute bioavailability of 98%. The metabolism of imatinib is mediated by the cytochrome P450 (CYP) isoenzymes in the liver and gut wall. CGP74588 is a major active metabolite of ima...

nuclear medicine imaging is routinely used for evaluation of perfusion and function of the transplanted kidneys. at present, the radiopharmaceutical of choice for this study in our center is tc 99m-ec. complications of the kidney graft are demonstrable in the early and delayed images. one of these complications is vesicoureteral reflux to the graft or to the native kidneys. we present a 27 year...

ObjectivesEx vivo lung perfusion provides an innovative method to assess and repair donor lungs. The current Toronto ex protocol can reliably reproducibly preserve lungs for 12 hours. A longer preservation time could enable the application of more advanced therapies rescue transplant. Our objective was achieve stable 24-hour normothermic perfusion.MethodsWe systematically examined 3 modificatio...

Electrical Impedance Tomography (EIT) is mainly used to display information about the respiration of a patient. However, also cardiac-related signals are present, and, although they have small amplitude, can be distinguished by their frequencies. In this contribution, we report method based on harmonic analysis separate and perfusion. These described summation amplitude-modulated at different W...

Oxygen metabolism is a key factor in the life of living organism. The article first part review methods for measuring oxygen metabolism. Purpose. aim this to present an insight into evolution way from global local measurement brain perfusion. role 15 O isotope as “gold standard” using positron emission tomography (PET) described. We also provide case report tumor perfusion measurements our clin...

We used real-time LDI to study regional variations in microcirculatory perfusion in healthy candidates to establish a new methodology for global perfusion body mapping that is based on intra-individual perfusion index ratios. Our study included 74 (37 female) healthy volunteers aged between 22 and 30 years (mean 24.49). Imaging was performed using a recent microcirculation-imaging camera (EasyL...

Sensing technology provides quantitative characterization of blood flow, hydration, perfusion, skin temperature, and thermal transport properties.