Sepsis is associated with increased intestinal permeability, but mediators and mechanisms are not fully understood. We examined the role of interleukin (IL)-6 and IL-10 in sepsis-induced increase in intestinal permeability. Intestinal permeability was measured in IL-6 knockout (IL-6 -/-) and wild-type (IL-6 +/+) mice 16 h after induction of sepsis by cecal ligation and puncture or sham operatio...

Increased cerebrovascular permeability is an important factor in the development of cerebral edema after stroke, implicating the blood-brain barrier (BBB) in the pathology of stroke. Present investigations modeled stroke at the level of the cerebral capillary endothelium by analyzing BBB permeability changes to the membrane-impermeant marker [14C]sucrose after hypoxia/aglycemia. Under hypoxia a...

The biopharmaceutics classification system (BCS) and biopharmaceutics drug distribution classification system (BDDCS) are complementary classification systems that can improve, simplify, and accelerate drug discovery, development, and regulatory processes. Drug permeability has been widely accepted as a screening tool for determining intestinal absorption via the BCS during the drug development...

Current instrumentation in vitreous fluorophotometry allows the determination of a fluorescein concentration profile along the optical axis of the eye. Based on an assumption of a uniform blood-retinal barrier permeability, several methods have been used for the determination of the permeability from an axial scan. The assumption of a uniform permeability is not realistic and it has been unknow...

The results presented in this study establish an association between phospholipase C-beta (PLC-beta) and tight junction permeability across Madin-Darby canine kidney (MDCK) cell monolayers, an in vitro model for epithelial tissue. These results further show that PLC-beta modulates tight junction permeability by affecting actin filament organization. Hexadecylphosphocholine (HPC) inhibited PLC-b...

Hydrotropy refers to increasing the water solubility of otherwise poorly soluble compound by the presence of small organic molecules. While it can certainly increase the apparent solubility of a lipophilic drug, the effect of hydrotropy on the drugs' permeation through the intestinal membrane has not been studied. The purpose of this work was to investigate the solubility-permeability interplay...

Water injection is used as a widespread IOR/EOR method and promising formation damages (especially mechanical ones) is a crucial challenge in the near-wellbore of injection wells. The magnesium oxide (MgO) NanoParticles (NPs) considered in the article underwater flooding experiment tests to monitor the promising mechanical formation damage (size exclusion) in lab mechanistic scale include m...

as regards if curing stops for some time and then resumes again, then strength gain will also stop and reactive, in this study with choose suitable curing conditions after improper first curing (recurring) for normal and silica-fume concrete, effect of this curing conditions on strength and permeability was investigated. the results from tests such as compressive strength, capillary water absor...

for button mushrooms packaging, the packaging films with high permeability to oxygen and carbon dioxide are required. permeability of plastic films such as pvc lead to loss of weight (and thus economic value) and textural changes are undesirable for button mushroom. so packaging film of polyolefins (pd 941 and pd 961) can be used. also the new film, hydrophilic materials such as films made from...