نتایج جستجو برای: peroxisome biogenesis

تعداد نتایج: 36041  

Journal: :genetics in the 3rd millennium 0
کامران قائدی kamran ghaedi department of genetics, biology group, sience faculty, isfahan university,isfahan, iran/ royan institute, isfahan research campus یوسف شفقتی yousef shafeghati

peroxisomes are single membrane bound organelles present in a wide variety of eukaryotes from yeast to human, have different functions, two of which are well conserved, i.e. hydrogen peroxide decomposition and fatty acid beta-oxidation. the process of peroxisome biogenesis can be divided into distinct steps including peroxisome membrane assembly, import of matrix proteins and peroxisome prolife...

Journal: :journal of sciences, islamic republic of iran 2009
k. ghaedi

we searched for novel chinese hamster ovary (cho) cell mutants defective in peroxisome biogenesis by an improved method using peroxisome targeting sequence (pts) of pex3p (amino acid residues 1–40)-fused enhanced green fluorescent protein (egfp). from mutagenized tkaeg3(1–40) cells, the wild-type cho-k1 stably expressing rat pex2p and of rat pex3p(1–40)-egfp, numerous cell colonies resistant to...

Journal: :genetics in the 3rd millennium 0
kamran ghaedi yousef shafeghati mohammad hossein nasr esfahani

in this presentation, we review briefly on biogenesis of peroxisomes with regard to the recent findings on biogenesis. peroxisomes perform a range of various functions as oxidation of very long chain fatty acids, generation and removal of hydrogen peroxide, while peroxisomes have also been implicated in β-oxidation of aromatic and cyclic compounds, synthesis of plasmalogens, isoprenoids, lysine...

Journal: :genetics in the 3rd millennium 0
kamran ghaedi yousef shafeghati mohammad hossein nasr esfahani

in this presentation, we review briefly on biogenesis of peroxisomes with regard to the recent findings on biogenesis. peroxisomes perform a range of various functions as oxidation of very long chain fatty acids, generation and removal of hydrogen peroxide, while peroxisomes have also been implicated in β-oxidation of aromatic and cyclic compounds, synthesis of plasmalogens, isoprenoids, lysine...

K. Ghaedi

We searched for novel Chinese hamster ovary (CHO) cell mutants defective in peroxisome biogenesis by an improved method using peroxisome targeting sequence (PTS) of Pex3p (amino acid residues 1–40)-fused enhanced green fluorescent protein (EGFP). From mutagenized TKaEG3(1–40) cells, the wild-type CHO-K1 stably expressing rat Pex2p and of rat Pex3p(1–40)-EGFP, numerous cell colonies resistant to...

Journal: :Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2006

Journal: :The Journal of Cell Biology 2008
Ramsey A. Saleem Barbara Knoblach Fred D. Mast Jennifer J. Smith John Boyle C. Melissa Dobson Rose Long-O'Donnell Richard A. Rachubinski John D. Aitchison

Reversible phosphorylation is the most common posttranslational modification used in the regulation of cellular processes. This study of phosphatases and kinases required for peroxisome biogenesis is the first genome-wide analysis of phosphorylation events controlling organelle biogenesis. We evaluate signaling molecule deletion strains of the yeast Saccharomyces cerevisiae for presence of a gr...

2013
Kevin Berendse Merel S Ebberink Lodewijk IJlst Bwee Tien Poll-The Ronald J A Wanders Hans R Waterham

BACKGROUND Zellweger spectrum disorders (ZSDs) are multisystem genetic disorders caused by a lack of functional peroxisomes, due to mutations in one of the PEX genes, encoding proteins involved in peroxisome biogenesis. The phenotypic spectrum of ZSDs ranges from an early lethal form to much milder presentations. In cultured skin fibroblasts from mildly affected patients, peroxisome biogenesis ...

Journal: :Proceedings of the Japan Academy, Series B 2016

2011
Changle Ma Gaurav Agrawal Suresh Subramani

The biogenesis of peroxisomal matrix and membrane proteins is substantially different from the biogenesis of proteins of other subcellular compartments, such as mitochondria and chloroplasts, that are of endosymbiotic origin. Proteins are targeted to the peroxisome matrix through interactions between specific targeting sequences and receptor proteins, followed by protein translocation across th...

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