نتایج جستجو برای: peroxisome proliferator
تعداد نتایج: 15330 فیلتر نتایج به سال:
conclusions in conclusion, as this mutation is present in a highly conserved region and any change in this region would adversely affect the protein structure and function, so the prevalence of this mutation is very low. background diabetes is an alarmingly increasing public health concern. according to a world health organization (who) report, diabetes is highly prevalent in almost all regions...
discussions in comparison to the control of wy14643, sandoz58-035, c9 and t11-cla, epa increased the pparα mrna levels (p = 0.024, p = 0.041, p = 0.043, and p = 0.004, respectively), even though, la had no significant effect on the pparα mrna expression (p = 0.489). materials and methods this experimental study investigated the effects of c9, t11-conjugated linoleic acid (c9, t11-cla). alpha li...
Biochemical Effects of Some Peroxisome Proliferator Activated Receptor Ligands in Hyperhomocysteinemic-ratsGhada M. Al-Ashmawy, Hoda A. El-Bahrawy, Nahla E. El-Ashmawy
Background & Aims: It has been shown that some drugs such as Pentoxifylline (PTX) have immunomodulatory and anti-inflammatory activity that might represent a potential preventive therapy for autoimmune diseases. The purpose of this study was to investigate the therapeutic effects of pentoxifylline on the treatment of autoimmune diabetes in mice and its effects on expressions of peroxisome proli...
objective(s): herbal medicines are promising cancer preventive candidates. it has been shown that punica granatum l. could inhibit angiogenesis and tumor invasion. in this study, we investigated whether the anti-angiogenic effect of pomegranate peel extract (ppe) is partly attributable to peroxisome proliferator-activated receptors (ppars) activation in the human umbilical vein endothelial cell...
PURPOSE To assess the effects of Aleglitazar on hyperglycaemia-induced apoptosis. METHODS We incubated human cardiomyocytes, cardiomyocytes from cardiac-specific peroxisome proliferator-activated receptor-γ knockout or wild-type mice in normoglycaemic or hyperglycaemic conditions (glucose 25 mM). Cells were treated with different concentrations of Aleglitazar for 48 h. We measured viability, ...
1. Dubuquoy L, Jansson EA, Deeb S, et al. Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis. Gastroenterology. 2003;124(5):1265-1276. doi:10.1016/s0016-5085(03)00271-3 CrossRef Google Scholar
Imatinib is actively transported by organic cation transporter-1 (OCT-1) influx transporter, and low OCT-1 activity in diagnostic chronic myeloid leukemia blood mononuclear cells is significantly associated with poor molecular response to imatinib. Herein we report that, in diagnostic chronic myeloid leukemia mononuclear cells and BCR-ABL1+ cell lines, peroxisome proliferator-activated receptor...
Peroxisome proliferator-activated receptors are nuclear receptors that were isolated for their ability to modulate lipid metabolism. Similar to other members of the nuclear receptor family, peroxisome proliferator-activated receptors bind ligand as heterodimers and exert their effects via transcriptional regulation through their DNA binding domains. During the past decade, it has become clear t...
A peroxisome proliferator-responsive element is located in the 5'-flanking region of the gene encoding rat hydratase-dehydrogenase, the second enzyme of the peroxisomal beta-oxidation pathway. DNase I footprint analysis with nuclear extracts from proliferator-responsive rat H4IIEC3 cells revealed two protected regions within the 196-base pair peroxisome proliferator-responsive element. Both reg...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید