background: alzheimer’s disease (ad) is a progressive neurodegenerative disease and nowadays the role of endothelial cell (ec) injury has been proposed in pathological process in ad. peroxisome proliferator‑activated receptor‑γ (ppar‑γ) agonist has anti‑inflammatory properties through activation in glial cells and improves vascular function and prevent atherosclerotic disease progression. the a...

Alzheimer’s disease (AD) is undoubtedly one of the serious and growing public health challenges in the world today. There is an unmet need for new and effective preventative and therapeutic treatment approaches for AD, particularly at early stages of the disease. However, the underlying mechanism against Aβ-induced electrophysiological alteration in cultured hippocampal pyramidal neurons  is st...