نتایج جستجو برای: pet 26b

تعداد نتایج: 54021  

ژورنال: :فصلنامه علمی پژوهشی دنیای میکروب ها 2014
اشرف کریمی نیک کبری سعیدی

سابقه و هدف: آلفا آمیلاز یک اندونوکلئاز می باشد که با شکستن پیوند داخلی آلفا 1 و 4 آمیلوز، آمیلوپکتین و گلیکوژن را هیدرولیز می نماید. امروزه گونه های مختلف جنس باسیلوس منبع مهمی در تولید این آنزیم به شمار می روند. این مطالعه با هدف همسانه سازی و بیان ژن کد کننده آلفا آمیلاز (amys) از باکتری باسیلوس لیکنیفورمیس و تعیین خصوصیات بیوشیمیایی آنزیم نوترکیب انجام شد. مواد و روش ها: توالی ژن مربوط به آ...

Journal: :Advanced pharmaceutical bulletin 2014
Salman Asghari Mahmoud Shekari Khaniani Masood Darabi Sima Mansoori Derakhshan

PURPOSE Stem cell factor (SCF) plays an important role in the survival, proliferation and differentiation of hematopoietic stem cells and progenitor cells. Potential therapeutic applications of SCF include hematopoietic stem cell mobilization, exvivo stem/progenitor cell expansion, gene therapy, and immunotherapy. Considering the cost and problem in accessibility of this product in Iran, clears...

2016
Lei Shi Wei Yin Zhiyu Zhang Guanggang Shi

Therapy against nasopharyngeal carcinoma (NPC) is hurdled by chemoresistance. Recent studies found that microRNA (miRNA) are important regulators of cancer resistance. In this study, we aimed to explore the role and mechanism of miR-26b in regulating NPC cisplatin (CDDP) resistance. Real-time PCR was used to evaluate miR-26b levels in CDDP-resistant and CDDP-sensitive NPC cells, as well as huma...

2016
Yong Wang Baocun Sun Xiulan Zhao Nan Zhao Ran Sun Dongwang Zhu Yanhui Zhang Yanlei Li Qiang Gu Xueyi Dong Meili Wang Jindan An

UNLABELLED Twist1 is well known to induce epithelial-mesenchymal transition (EMT) and promote tumor metastasis. MicroRNAs (miRNAs) are involved in the EMT process and are associated with metastasis in hepatocellular carcinoma (HCC). In the present study, microRNA-26b-5p (miR-26b-5p) expression was consistently and significantly downregulated in HepG2-Twist1 HCC cell lines compared with HepG2-ve...

2016
Ming-Ming Tsai Hsiang-Wei Huang Chia-Siu Wang Kam-Fai Lee Chung-Ying Tsai Pei-Hsuan Lu Hsiang-Cheng Chi Yang-Hsiang Lin Liang-Mou Kuo Kwang-Huei Lin

MicroRNAs (miRNA) play an important role in carcinogenesis. Previously, we identified miR-26b as a significantly downregulated miRNA in gastric cancer (GC) tissues (n = 106) based on differential quantitative RT-PCR (RT-qPCR) miRNA expression profiles. In the current study, we aimed to clarify the potential role of miR-26b and related target genes in GC progression. Downregulation of miR-26b wa...

Journal: :Genetics and molecular research : GMR 2015
W D Zheng F L Zhou N Lin

MicroRNAs regulate target gene expression and are involved in cell proliferation, apoptosis, differentiation, tumor invasion, and cancer stem cell regulation, among other processes. MicroRNA-26b (miR-26b) is closely related to tumor occurrence and development. In this study, we analyzed miR-26b expression in osteosarcoma tissue, its effect on Saos-2 osteosarcoma cell proliferation and invasion,...

2011
Ning Wu Xiangzhong Zhao Ming Liu Haizhou Liu Weicheng Yao Yuyan Zhang Shousong Cao Xiukun Lin

BACKGROUND MicroRNAs (miRNAs) are short, non-coding RNAs that regulate the expression of multiple target genes. Deregulation of miRNAs is common in human tumorigenesis. Low level expression of miR-26b has been found in glioma cells. However, its underlying mechanism of action has not been determined. METHODOLOGY/PRINCIPAL FINDINGS Real-time PCR was employed to measure the expression level of ...

2015
Jiaxin Lin Lan Zhang He Huang Yongwen Huang Long Huang Jianhua Wang Shuting Huang Li He Yun Zhou Weihua Jia Jingping Yun Rongzhen Luo Min Zheng

Karyopherin alpha 2 (KPNA2) is a nuclear transport protein upregulated in many cancers. Our previous study has identified KPNA2 overexpression in epithelial ovarian carcinoma (EOC) tissues, which predicts poor prognosis. However, the mechanism of KPNA2 overexpression in EOC remains unclear. This study aimed to examine the role of miRNA in KPNA2 dysregulation. Our results showed that miR-26b was...

Journal: :International journal of clinical and experimental pathology 2015
Hesheng Li Qinglei Sun Bing Han Xingquan Yu Baoguang Hu Sanyuan Hu

Deregulated microRNAs (miRNAs) have been shown to play important roles in cancer progression as a result of changes in expression of their target genes. In this study, we investigated the expression of miR-16b in eight hepatocellular carcinoma (HCC) cell lines, revealed the roles of miR-26b on hepatocellular carcinoma (HCC) cell proliferation, migration, and invasion, and confirmed that EphA2 i...

2015
Natalya Benderska Anna-Lena Dittrich Sabine Knaup Tilman T. Rau Clemens Neufert Sven Wach Fabian B. Fahlbusch Manfred Rauh Ralph M. Wirtz Abbas Agaimy Swetha Srinivasan Vijayalakshmi Mahadevan Petra Rümmele Emmanouela Rapti Maria Gazouli Arndt Hartmann Regine Schneider-Stock

BACKGROUND Longstanding ulcerative colitis (UC) bears a high risk for development of UC-associated colorectal carcinoma (UCC). The inflammatory microenvironment influences microRNA expression, which in turn deregulates target gene expression. microRNA-26b (miR-26b) was shown to be instrumental in normal tissue growth and differentiation. Thus, we aimed to investigate the impact of miR-26b in in...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید