نتایج جستجو برای: pharmacokinetic

تعداد نتایج: 25201  

Journal: :iranian journal of pharmaceutical research 0
n hadavand m mojtahedzadeh s sadray r shariat moharreri mr khajavi p salari

the effect of positive end expiratory pressure (peep) on the hepatic elimination of low to moderate extraction ratio drugs has not been clearly defined. we prospectively investigated the effect of peep on the clearance of theophylline in 30 (20 males and 10 females) intubated critically ill adult patients with acute lung injury/acute respiratory distress syndrome (ali/ards). the mean (±sd) age ...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2005
Huadong Tang Michael Mayersohn

A general equation was derived, which directly describes the mathematical relationship between the allometrically predicted pharmacokinetic (PK) parameters in humans and the body weights of animal species (along with their corresponding measured PK parameters). It was shown, with use of the derived equation, that the predicted values in humans, based on combinations of animal species commonly u...

Journal: :iranian journal of pharmaceutical sciences 0
hamid r. sadeghnia faculty of pharmacy and pharmaceutical sciences research center, mashhad university of medical sciences, mashhad, iran mohammad hassanzadeh-khayyat faculty of pharmacy and pharmaceutical sciences research center, mashhad university of medical sciences, mashhad, iran

in this study, the pharmacokinetic parameters of two marketed tablet formulations of ketoconazole were studied, and the relative bioavailability of the test formulation was compared with a reference formulation. a single dose (12x2) double blind randomized cross-over study of a generic formulation of ketoconazole tablet (2x200 mg), and a commercial brand, nizoral tablet (2x200 mg, janssen pharm...

Journal: :iranian journal of basic medical sciences 0
tamara aghebati pharmaceutical research centre, mashhad university of medical sciences, mashhad, iran mohsen foroughipour department of neurology, faculty of medicine, ghaem hospital, mashhad university of medical sciences, mashhad, iran mahmoud reza azarpazhooh department of neurology, faculty of medicine, ghaem hospital, mashhad university of medical sciences, mashhad, iran naghme mokhber department of psychiatry, faculty of medicine & psychiatric research centre, ebn-sina hospital, mashad university of medical sciences, mashhad, iran mohammad hasanzadeh khayat pharmaceutical research centre, mashhad university of medical sciences, mashhad, iran department of medicinal chemistry, school of pharmacy, mashhad university of medical sciences, mashhad, iran

objective(s) as there are conflicting findings regarding the clearance-dose and patient characteristics relationships for valproic acid (vpa), this study was conducted to investigate the relationship between patient demographic characteristics, vpa dosage and the drug clearance in adult iranian patients. materials and methods patients (n= 47) were either on monotherapy with vpa or were under co...

Bilal Ashiq M. Imran Qadir, Mohsin Ali Muhammad Ashraf, Muhammad Imran Khokhar Muhammad Irfan Masood Muhammad Usman, Ovais Omer Shehryar Afzal

The aim of this study was to characterize the effect of typhoid fever on pharmacokinetic parameters of levofloxacin (LF) and compare the pharmacokinetic parameters of the said antibiotic in healthy human volunteers and patients with typhoid fever. Total of 12 subjects were divided into two groups “A” (healthy volunteers) and “B” (typhoid patients). Single oral dose of LF 500 mg was given and 5 ...

2017
Carolina L. Haass-Koffler Kimberly Goodyear Victoria M. Long Harrison H. Tran Antonella Loche Roberto Cacciaglia Robert M. Swift Lorenzo Leggio

The data in this article outline the methods used for the administration of GET 73 in the first time-in-human manuscript entitled "Phase I randomized clinical trial for the safety, tolerability and preliminary pharmacokinetics of the mGluR5 negative allosteric modulator GET 73 following single and repeated doses in healthy male volunteers" (Haass-Koffler et al., 2017) [1]. Data sets are provide...

Journal: :iranian journal of pharmaceutical research 0
zhen-qiu zhang liaoning university of traditional chinese medicine, 77 life one road, dd port, dalian 116600, china. wei liu liaoning university of traditional chinese medicine, 77 life one road, dd port, dalian 116600, china. li zhuang liaoning university of traditional chinese medicine, 77 life one road, dd port, dalian 116600, china. jing wang liaoning university of traditional chinese medicine, 77 life one road, dd port, dalian 116600, china. shuai zhang liaoning university of traditional chinese medicine, 77 life one road, dd port, dalian 116600, china.

the aim of this study was to investigate the pharmacokinetic profiles of baicalin, wogonoside, baicalein and wogonin after oral administration of pure baicalin, radix scutellariae and scutellariae-paeoniae couple extracts were administered and the pharmacokinetics profiles were compared between normal and ulcerative colitis rats. the plasma concentrations of the four flavonoids were determined ...

Bilal Ashiq M. Imran Qadir, Mohsin Ali Muhammad Ashraf, Muhammad Imran Khokhar Muhammad Irfan Masood Muhammad Usman, Ovais Omer Shehryar Afzal

The aim of this study was to characterize the effect of typhoid fever on pharmacokinetic parameters of levofloxacin (LF) and compare the pharmacokinetic parameters of the said antibiotic in healthy human volunteers and patients with typhoid fever. Total of 12 subjects were divided into two groups “A” (healthy volunteers) and “B” (typhoid patients). Single oral dose of LF 500 mg was given and 5 ...

M Abbasi Nazari N Khanzadeh Moqhadam

Concomitant use of several drugs by ICU( Intensive Care Unit) patients is often unavoidable. In these patients, pharmacokinetic drug interactions are very likely. The current study was designed to evaluate these interactions in patients hospitalized in an ICU of a teaching hospital in Tehran, Iran. A questionnaire was designed and used to collect study data. The study was done in the ICU of a t...

M Abbasi Nazari N Khanzadeh Moqhadam

Concomitant use of several drugs by ICU( Intensive Care Unit) patients is often unavoidable. In these patients, pharmacokinetic drug interactions are very likely. The current study was designed to evaluate these interactions in patients hospitalized in an ICU of a teaching hospital in Tehran, Iran. A questionnaire was designed and used to collect study data. The study was done in the ICU of a t...

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