BACKGROUND We aimed to evaluate whether area under the curve (AUC) analysis of pharmacodynamic data can be used to compare pharmacokinetic models taken from the literature, during a target controlled infusion (TCI) of rocuronium. METHODS Seventy-two patients scheduled for orthopaedic surgery received a TCI of rocuronium (Stanpump) based on one of four pharmacokinetic models: those described b...

The properties relevant to pharmacokinetics and pharmacodynamics of four series of synthesized s-triazine derivatives have been studied by Quantitative structure-retention relationship (QSRR) approach. The chromatographic behavior of these compounds was investigated by using reversed-phase high performance thin-layer chromatography (RP-HPTLC). Chromatographic retention (RM0) was correlated with...

Isosorbide dinitrate (ISDN) is an effective drug in treatment of angina pectoris. In this study a new generation of electron capture detector (non-radioactive) with a short, non-polar and wide-bore column was used for analysis of ISDN in human serum. ISDN was extracted from serum by a mixture of ether and ethyl acetate and concentrated at room temperature. The method was linear between 5-50...

The paper is devoted to various aspects of the organization drug pharmacokinetics research both at preclinical and clinical levels (bioequivalence study, therapeutic monitoring, optimization dosage regimens), as well arrangement work equipment (instrumentation, chemicals, premises, personnels) pharmacokinetic laboratory.

Pharmacokinetic (PK) studies of radiopharmaceuticals (RPs) are distinctive because small concentrations active ingredients. Whereas methods applicable to non-RP medicinal products cannot be used for RPs, radionuclide can provide an insight into behaviour. The aim the study was compare approaches pre-clinical PK evaluation RPs and other products. article describes main aspects non-RPs, defining ...

Pharmacokinetic studies are an integrated part of the development program of a new drug. They are intended to define the time course of drug and major metabolite concentrations in plasma and other biological fluids in order to obtain information on absorption, distribution, metabolism, and elimination. In preclinical studies, pharmacokinetics (PK) is often used to interpret toxicological result...

The propellant-free Combivent Respimat Soft Mist Inhaler (CVT-R) was developed to replace the chlorofluorocarbon-propelled Combivent metered-dose inhaler (CVT-MDI). This steady-state pharmacokinetic (PK) substudy evaluated drug lung-delivery efficiency, using data from two phase III safety and efficacy trials. PK parameters were obtained from well-controlled population PK analyses. Area under t...