The association between physiologically dependent pharmacokinetic parameters (CL(B), T1/2beta, Vd(ss)) of marbofloxacin and body weight was studied in eight animal species based on allometric equation Y = aWb, where 'Y' is the pharmacokinetic parameter, 'W' is body weight, 'a' is allometric coefficient (intercept) and 'b' is the exponent that describes relation between pharmacokinetic parameter...

The objective of the current study was to develop mathematical models that described the pharmacokinetic behavior of prednisolone in healthy subjects after the oral administration of prednisolone. The current study is a companion piece of a related Leclercq and Copinsehi prednisolone study published in the February 1974 issue of the Journal of Pharmacokinetics and Biopharmaceutics. In the study...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 drug‑drug interactions (ddis) are one of the commonest causes of medication error in developed countries, particularly in the elderly due to poly‑therapy, with a prevalence of 20‑40%. in particular, poly‑therapy increases the complexity of therapeutic management and thereby the risk of clinically important ddis, wh...

Drug development is very time consuming and costly process. Only few candidates enters in to clinical trials can eventually become a drug. Accurate prediction of the right dose before entering in to clinical study can reduce time as well as cost of drug discovery process. Pharmacokinetic plays an essential role in the selecting the right dose and dosage regimen [1-5]. Thus early prediction of h...

This study describes the maturation of sirolimus clearance in a cohort of very young pediatric patients with vascular anomalies. The relationship between allometrically scaled in vivo clearance and age was described by the Emax model in patients aged 1 month to 2 years. Consistent with the observed increase, in vitro intrinsic clearance of sirolimus using pediatric liver microsomes showed a sim...

The American Society of Health-System Pharmacists (ASHP) believes that clinical pharmacokinetic monitoring is a fundamental responsibility of all pharmacists providing pharmaceutical care. Clinical pharmacokinetic monitoring is an integral component of pharmaceutical care for selected patients based on their specific pharmacotherapy, disease states and related factors, and treatment goals. ASHP...

BACKGROUND AND OBJECTIVES Sifalimumab is a fully human immunoglobulin G1κ monoclonal antibody that binds to and neutralizes a majority of the subtypes of human interferon-α. Sifalimumab is being evaluated as a treatment for systemic lupus erythematosus (SLE). The primary objectives of this analysis were (a) to develop a population pharmacokinetic model for sifalimumab in SLE; (b) to identify an...

A 14-year-old male with bilateral above-the-knee amputations presented to our hospital for treatment of a skin and soft-tissue infection. We report the experience of vancomycin and gentamicin therapy in this patient. Because these medications require weight-based dosages and pharmacokinetic monitoring of serum levels, it was necessary to obtain peak and trough levels of the two drugs in order t...