Some studies showed that ceplukan (Physalis angulata Linn) have cytotoxic effects toward HeLa (cervical cancer), KB (Nasopharyngeal), Colo 205 (colon), Calu (Lung) and MCF-7 cells in vitro. This plant has cytotoxic effects toward rat P388 lymphocytic leukemia in vivo. One of the mechanisms of cytotoxicity is the inhibition of Cyclooxygenase-2 (COX-2) pathway. The purpose of this study was to de...

Fruit abscission as a response to herbivory is well-documented in many plant species, but its effect on further damage by mobile herbivores that survive fruit abscission is relatively unstudied. Physalis plants (Solanaceae) abscise fruit containing feeding larvae of their main frugivore, Heliothis subflexa Guenée (Lepidoptera: Noctuidae), a specialist moth. We tested the ability of H. subflexa ...

AIM OF THE STUDY The in vitro antiplasmodial activity and cytotoxicity of methanolic and dichloromethane extracts from five Congolese plants were evaluated. The plants were selected following an ethnobotanical survey conducted in D.R. Congo and focusing on plants used traditionally to treat malaria. The in vivo antimalarial activity of aqueous and methanolic extracts active in vitro was also de...

Withanolides are known as the main components of Physalis genus with broad biological activities. Using combination of various chromatographic methods, three withanolides were isolated including physagulin J (1), physagulin K (2), and physagulin N (3). Their chemical structures were determined by analysis of NMR spectra, and as well as comparison with reported literature. Compound 1 showed sign...

The study examine the antioxidant and antimicrobial potential of the ethanolic and aqueous leaf extracts of ten selected Indian medicinal plants namely, Psidium guajava, Mangifera indica, Polyalthia longifolia, Allium cepa, Phyllanthus amarus, Thespesia populnea, Ricinus communis, Physalis angulata, Ixora coccinea, and Vinca rosea using 2, 2-Diphenyl-1-picrylhydrazyl (DPPH) scavenging assay, to...

Physalis angulata L (Solanaceae) is a medicinal plant from North of Brazil, whose different extracts and infusions are commonly used in the popular medicine for the treatment of malaria, asthma, hepatitis, dermatitis and rheumatism. However, the genotoxic effects of P. angulata on human cells is not well known. The main purpose of the present study was to evaluate the in vitro genotoxic effects...

AIM To investigate the effects of Ground Cherry (Physalis angulata L.) standardized supercritical CO2 extract in trinitrobenzenesulphonic acid (TNBS) model of rat intestinal inflammation. METHODS The animals were divided into groups that received vehicle or P. angulata extract (PACO2) orally at the doses 25, 50 and 100 mg/kg daily by 5 d before TNBS damage. Protective effects of PACO2 were as...

BACKGROUND Leishmaniasis is an infectious disease caused by various species of the protozoan parasites of the Leishmania genus and transmitted by phlebotomine sandflies. The protozoa multiply in phagocytic cells, mainly macrophages, which play an important role defending the organism from pathogens. The most effective treatment for leishmaniasis is the chemotherapy and besides the high cost, th...

Physalis angulata L., Solanaceae, is an annual herb commonly used in popular medicine in many tropical and subtropical countries. P. angulata extracts contain a variety of substances, but little is known about their pharmacological activities. In this work we investigated the in vitro antileishmanial activity of seco-steroids (physalins) purified from P. angulata. Addition of physalins B, F, an...

Entre os diversos gêneros de Solanaceae, Physalis destaca-se por apresentar potencialidades comerciais relacionadas à culinária e farmacologia (TANAN, 2015), nesse a espécie angulata.