The objective of this review was to discuss whether endocrine disruption is a clinical concern in domestic animal reproduction. To that end, we firstly summarize the phenomenon of endocrine disruption, giving examples of the agents of concern and their effects on the mammalian reproductive system. Then there is a brief overview of the literature on endocrine disruptors and domestic animal repro...

This paper brings up regarding the plant derived compounds with estrogenic activity. The authors correctly emphasize the need for control of estrogenicity of foods containing phyto-oestrogens in view of the significant health effects of various estrogenic derivatives. This is particularly essential in the light of the current wave of enthusiasm for vegetarian food in general and phytooestrogens...

Plant-based diets contain a plethora of secondary metabolites that may impact on health and disease prevention. Much attention has been focused on the potential bioactivity and nutritional relevance of several classes of phytochemicals such as flavonoids, carotenoids, phytooestrogens and glucosinolates. Less attention has been paid to simple phenolic acids that are widely found in fruit, vegeta...

Members of the nuclear steroid hormone superfamily mediate essential physiological functions. Steroid hormone receptors (SHR) act directly on DNA, regulate the synthesis of their target genes and are usually activated by ligand binding. Both endogenous and exogenous compounds and their metabolites may act as activators of SHR and disruptors of endocrine, cellular and lipid homeostasis. The endo...

Endothelial dysfunction is widely considered as a prognostic marker of future cardiovascular events in clinical settings, even in patients who do not have untoward symptoms of cardiovascular disease. Thus, treatments aimed at restoring endothelial dysfunction have important implications Many studies have demonstrated that supplementary treatments can improve endothelial function. These favourab...

There is increasing evidence in favour of a link between diets high in soyabeans, a rich source of the isoflavones genistein and daidzein, and reduced incidence of colon cancer and hormone-dependent cancers, such as breast and prostate cancer (for review, see Bingham et al. 1998). A number of studies in animal models demonstrate a chemopreventive effect of soyabean and/or genistein. For example...

There is increasing evidence in favour of a link between diets high in soyabeans, a rich source of the isoflavones genistein and daidzein, and reduced incidence of colon cancer and hormone-dependent cancers, such as breast and prostate cancer (for review, see Bingham et al. 1998). A number of studies in animal models demonstrate a chemopreventive effect of soyabean and/or genistein. For example...

There is increasing evidence in favour of a link between diets high in soyabeans, a rich source of the isoflavones genistein and daidzein, and reduced incidence of colon cancer and hormone-dependent cancers, such as breast and prostate cancer (for review, see Bingham et al. 1998). A number of studies in animal models demonstrate a chemopreventive effect of soyabean and/or genistein. For example...